Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations
| Autor: | Marcos Augusto Mauad, Talita Chaves Martins, Clarissa Vasconcellos de Souza, Ariana Alves Paixão, Márcia de Matos Silva, Afonso Celso Vigorito, Maria Claudia Novo Leal Rodrigues, E.C. Nunes, Luis Fernando Bouzas, Érika Pallottino, Rita de Cássia Barbosa da Silva Tavares, Maria Elvira Pizzigatti Correa, Mary E.D. Flowers, Alessandra B. Ferrari, Vaneusa A. M. Funke |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry lcsh:RC633-647.5 Mucocutaneous zone Alternative medicine Consensus criteria Hematopoietic stem cell transplantation Hematology Disease lcsh:Diseases of the blood and blood-forming organs Graft vs. host disease/classification medicine.disease Graft vs. host disease Clinical trial Grip strength Graft-versus-host disease Walk test Physical therapy Medicine Training Original Article business Graft vs. host disease/diagnosis |
| Zdroj: | Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia, Vol 33, Iss 5, Pp 358-366 (2011) Revista Brasileira de Hematologia e Hemoterapia v.33 n.5 2011 Revista brasileira de hematologia e hemoterapia Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC Revista Brasileira de Hematologia e Hemoterapia, Volume: 33, Issue: 5, Pages: 358-366, Published: OCT 2011 |
| ISSN: | 1806-0870 |
| Popis: | BACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials. METHODS: Here we describe a one-day workshop model conducted by the Chronic Graft-versus-Host Disease Brazil-Seattle Consortium Study Group to train investigators interested in participating in multicenter clinical trials in Brazil. Workshop participants included eight transplant physicians, one dermatologist, two dentists, three physical therapists and one psychologist from five institutions. Workshop participants evaluated nine patients with varying degrees of severity of mucocutaneous lesions and other manifestations of the disease followed by a training session to review and discuss the issues encountered with the evaluation and scoring of patients and in the methods used to evaluate grip strength and the 2-minute walk test. RESULTS: Most participants had difficulties in rating the percentage of each type of mucocutaneous lesion and thought 20 minutes was insufficient to evaluate and record the scores of each patient using the National Institutes of Health criteria and other cutaneous assessments. Several specific areas of difficulties encountered by the evaluators were: 1) determining the percentage of erythema in movable and non-movable sclerosis, 2) whether to score all cutaneous findings in a particular area or just the dominant lesion; 3) clarification of the definition of poikiloderma in chronic graft-versus-host disease; 4) discrepant interpretation of the mouth score and 5) clarification on the methodology used for the evaluation of grip strength and the 2-minute walk tests. CONCLUSIONS: Results of this workshop support the need to train investigators participating in clinical trials on chronic graft-versus-host disease. |
| Databáze: | OpenAIRE |
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