Excessively elevated C-reactive protein after surgery for temporal lobe epilepsy
| Autor: | Marie-Angela Wulf, Marian Christoph Neidert, Jan-Karl Burkhardt, René-Ludwig Bernays, Christoph M. Woernle, Thomas Grunwald |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Drug Resistance Hippocampus Neurosurgical Procedures Temporal lobe Epilepsy Young Adult Postoperative Complications Refractory Seizures Medicine Humans Epilepsy surgery Child Aged Retrospective Studies Brain Chemistry Inflammation biology business.industry C-reactive protein Amygdalohippocampectomy Seizure outcome Supratentorial Neoplasms General Medicine Middle Aged medicine.disease Amygdala Magnetic Resonance Imaging Surgery Kinetics C-Reactive Protein Treatment Outcome Epilepsy Temporal Lobe Anesthesia Child Preschool biology.protein Anticonvulsants Female Neurology (clinical) Neurosurgery Nervous System Diseases business |
| Zdroj: | Clinical neurology and neurosurgery. 115(8) |
| ISSN: | 1872-6968 |
| Popis: | We present a series of 87 patients who underwent anteromesial temporal lobe resections for therapy refractory temporal lobe epilepsy. In addition to seizure outcome, we observed excessively elevated CRP-levels in this patient population.We followed 87 patients (m=39, f=48; mean age 33.73±12.92, range 5-67 years) who underwent surgery between July 2003 and November 2011. Seizure outcome was classified in all patients according to the ILAE-classification by Wieser et al. (mean follow-up: 38.72 months). CRP levels were measured in 59 patients of the epilepsy surgery group and in a control group of 44 consecutive patients with supratentorial tumors (22 glioblastomas, 22 meningiomas).Clinical benefit was seen in 96.6% of the patients (ILAE classes 1-4), 80.5% were completely seizure free (ILAE class 1). Post-OP CRP values were significantly higher in the epilepsy group (n=59; mean CRP peak value: 100.86 mg/l, range: 16-258 mg/l) compared to the control group (n=44; mean CRP peak value: 36.85 mg/l, range: 0.4-233 mg/l) (p0.001), but the correlation of mean CRP value and mean temperature peak is weak (r=0.31).Seizure outcome after surgery for temporal lobe epilepsy was excellent, CRP levels were excessively elevated in these patients in the absence of clinical infection and significantly higher compared to resections of supratentorial lesions. |
| Databáze: | OpenAIRE |
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