Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress
| Autor: | Yuan-Shan Zeng, Ya-jing Qin, Jiu-Yu Tang, Qiao-Ge Chen, Zhi-Qiang Zhong, Sui-Jun Chen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Sucrose medicine.medical_specialty Sodium Drinking chemistry.chemical_element Body weight law.invention Rats Sprague-Dawley chemistry.chemical_compound law Mild stress Internal medicine Animals Medicine Chronic stress Fluoxetine biology Depression business.industry Body Weight biology.organism_classification Rats Endocrinology Rhodiola rosea Complementary and alternative medicine chemistry Biochemistry Rhodiola business Phytotherapy Stress Psychological Drugs Chinese Herbal medicine.drug |
| Zdroj: | Journal of Chinese Integrative Medicine. 6:952-955 |
| ISSN: | 1672-1977 |
| DOI: | 10.3736/jcim20080915 |
| Popis: | Objective To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.dz Methods A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week. Results After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group. Conclusion Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|