Peroxisomes Are Critical for the Development and Maintenance of B1 and Marginal Zone B Cells but Dispensable for Follicular B Cells and T Cells
| Autor: | Jonathan Muri, Basak Corak, Mai Matsushita, Myriam Baes, Manfred Kopf |
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| Rok vydání: | 2022 |
| Předmět: |
Mice
Knockout Peroxisome-Targeting Signal 1 Receptor Lymphoid Tissue Lymphopoiesis Immunology B-Lymphocyte Subsets Cell Differentiation Germinal Center Pneumococcal Infections Immunophenotyping Mice Oxidative Stress Streptococcus pneumoniae T-Lymphocyte Subsets Antibody Formation Host-Pathogen Interactions Peroxisomes Animals Immunology and Allergy Immunization Disease Susceptibility Oxidation-Reduction Biomarkers |
| Zdroj: | The Journal of Immunology. 208:839-850 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Antioxidant systems maintain cellular redox (oxidation-reduction) homeostasis. In contrast with other key redox pathways, such as the thioredoxin system, glutathione, and NF-E2-related factor 2 (Nrf2), little is known about the function of the redox-sensitive organelle “peroxisome” in immune cells. In this study, we show that the absence of peroxisomes in conditional Pex5-deficient mice strikingly results in impaired homeostatic maintenance of innate-like B cells, namely, B1 and marginal zone B cells, which translates into a defective Ab response to Streptococcus pneumoniae. Surprisingly, however, follicular B2 cell development, homeostatic maintenance, germinal center reactions, Ab production, class switching, and B cell memory formation were unaffected in Pex5-deficient animals. Similarly, T cell development and responses to viral infections also remained unaltered in the absence of Pex5. Thus, this study highlights the differential requirement of peroxisomes in distinct lymphocyte subtypes and may provide a rationale for specifically targeting peroxisomal metabolism in innate-like B cells in certain forms of B cell malignancies involving B1 cells. |
| Databáze: | OpenAIRE |
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