B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients
| Autor: | Hector Rincon-Arevalo, Alexander Potekhin, Ana-Luisa Stefanski, Arne Sattler, Hubert Schrezenmeier, Charlotte Hammett, Eva Schrezenmeier, Kai-Uwe Eckardt, Thomas Doerner, Fabian Halleck, Friederike Bachmann, Vanessa Pross, Henriette Staub-Hohenbleicher, Klemens Budde, Bernd Jahrsdörfer, Katja Kotsch, Mira Choi, Carolin Ludwig, Andreia C. Lino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
education.field_of_study Cellular immunity business.industry T cell Population Heterologous General Medicine 3. Good health Serology Vaccination 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Nephrology Immunity Rapid Communications Immunology medicine 030212 general & internal medicine Seroconversion education business 030304 developmental biology |
| Zdroj: | J Am Soc Nephrol |
| Popis: | BACKGROUND: Accumulating evidence sugges ts solid organ transplant recipients, as opposed to the general population, show strongly impaired responsiveness toward standard SARS-CoV-2 mRNA-based vaccination, demanding alternative strategies for protectio n o f this vulnerable group. METHODS: In line with recent recommendations, a third dose of either heterologous ChAdOx1 (AstraZeneca) or homologous BNT162b2 (BioNTech) was administered to 25 kidney transplant recipients (KTR) without humoral response after two doses of BNT162b2, followed by analysis of serological responses and vaccine-specific B- and T-cell immunity. RESULTS: Nine out of 25 (36%) KTR under standard immunosuppressive treatment seroconverted until day 27 after the third vaccination, whereas one patient developed severe COVID-19 infection immediately after vaccination. Cellular analysis 7 days after the third dose showed significantly elevated frequencies of viral spike-protein receptor-binding domain-specific B cells in humor al responders as compared with nonresponders. Likewise, portions of spike-reactive CD4(+) T helper cells were significantly elevated in patients who were seroconverting. Furthermore, overall frequencies of IL-2(+), IL-4(+), and polyfunctional CD4(+) T cells significantly increased after the third dose, whereas memory/effector differentiation remained unaffected. CONCLUSIONS: Our data suggest a fraction of transplant recipients benefit from triple vaccination, where seroconversion is associated with quantitative and qualitative changes of cellular immunity. At the same time, the study highlights that modified vaccination approaches for immunosuppressed patients remain an urgent medical need. PODCAST: This article contains a podcast athttps://www.asn-online.org/media/podcast/JASN/2021_11_23_briggsgriffin112321.mp3 |
| Databáze: | OpenAIRE |
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