A 2-year longitudinal study of neuropsychological functioning, psychosocial adjustment and rehospitalisation in schizophrenia and major depression

Autor: Charypar Marketa, Engel Rolf, Schaub Annette, Goerigk Stephan, Hautzinger Martin, Falkai Peter, Möller Hans-Jürgen, Goldmann Ulrich, Roth Elisabeth, Kim T. Mueser
Rok vydání: 2020
Předmět:
Adult
Male
Health Knowledge
Attitudes
Practice
Longitudinal study
Cognitive-behavioral therapy
medicine.medical_treatment
Illness management
Emotional Adjustment
Patient Readmission
Psychosocial functioning
Young Adult
03 medical and health sciences
0302 clinical medicine
Patient Education as Topic
Adaptation
Psychological
Outcome Assessment
Health Care
Psychoeducation
Major depression
Humans
Medicine
Cognitive Dysfunction
Pharmacology (medical)
Neuropsychological functioning
Longitudinal Studies
Biological Psychiatry
Depression (differential diagnoses)
Aged
Original Paper
Depressive Disorder
Major
Cognitive Behavioral Therapy
business.industry
Neuropsychology
General Medicine
Middle Aged
Moderation
medicine.disease
030227 psychiatry
Cognitive behavioral therapy
Psychiatry and Mental health
Rehospitalisation rate
Schizophrenia
Female
business
Social Adjustment
Psychosocial
030217 neurology & neurosurgery
Clinical psychology
Zdroj: European Archives of Psychiatry and Clinical Neuroscience
ISSN: 1433-8491
0940-1334
DOI: 10.1007/s00406-020-01118-x
Popis: Neuropsychological functioning turns out to be a rate-limiting factor in psychiatry. However, little is known when comparing neuropsychological and psychosocial functioning in inpatients with schizophrenia or severe depression in their treatment pathways including add-on psychoeducation or the latter combined with cognitive behavioral therapy up to 2-year follow-up. To evaluate this question, we investigated these variables in two randomised controlled trials including 196 patients with DSM-IV schizophrenia and 177 patients with major depression. Outcome measures were assessed in the hospital at pre- and posttreatment and following discharge until 2-year follow-up. We focused on neuropsychological and psychosocial functioning regarding its differences and changes over time in data of two pooled trials. There were significant time effects indicating gains in knowledge about the illness, short and medium-term memory (VLMT) and psychosocial functioning (GAF), however, the latter was the only variable showing a time x study/diagnosis interaction effect at 2-year follow-up, showing significant better outcome in depression compared to schizophrenia. Moderator analysis showed no changes in psychosocial and neuropsychological functioning in schizophrenia and in affective disorders due to age, duration of illness or sex. Looking at the rehospitalisation rates there were no significant differences between both disorders. Both groups treated with psychoeducation or a combination of psychoeducation and CBT improved in neuropsychological and psychosocial functioning as well as knowledge about the illness at 2-year follow-up, however, patients with major depression showed greater gains in psychosocial functioning compared to patients with schizophrenia. Possible implications of these findings were discussed. Electronic supplementary material The online version of this article (10.1007/s00406-020-01118-x) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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