Copper‐Catalyzed Oxidative Cross‐Coupling of Electron‐Deficient Polyfluorophenylboronate Esters with Terminal Alkynes

Autor:	Alexandra Friedrich, Todd B. Marder, Mingming Huang, Udo Radius, Zhiqiang Liu, Stephen A. Westcott, Ya-Ming Tian, Yudha P. Budiman
Rok vydání:	2020
Předmět:	fluoroarenes chemistry.chemical_element Sonogashira coupling Oxidative phosphorylation coupling reactions 010402 general chemistry 01 natural sciences Catalysis Coupling reaction chemistry.chemical_compound Full Paper 010405 organic chemistry Organic Chemistry Substrate (chemistry) Fluorine General Chemistry Full Papers Combinatorial chemistry 0104 chemical sciences Coupling (electronics) chemistry Terminal (electronics) ddc:540 Functional group Sonogashira reaction boronate esters
Zdroj:	Chemistry (Weinheim an Der Bergstrasse, Germany)
ISSN:	1521-3765 0947-6539
Popis:	We report herein a mild procedure for the copper‐catalyzed oxidative cross‐coupling of electron‐deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross‐coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction. BFF: A mild procedure is reported for the synthesis of alkynyl(fluoro)arenes via copper‐catalyzed oxidative cross‐coupling of polyfluorophenylboronate esters with terminal alkynes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effe1cec1cb927918a70fbd5e53e90b6 https://doi.org/10.1002/chem.202002888 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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