Beneficial effects of exercise training in heart failure are lost in male diabetic rats
| Autor: | Alain Cohen-Solal, Claude Delcayre, Mathilde Prud’homme, Dalila Boudia, Valérie Domergue, Héloïse Prigent, Jane-Lise Samuel, Renée Ventura-Clapier, Loubina Fazal, Anne Garnier, Philippe Mateo |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Physiology Rat model Myocardial Infarction 030204 cardiovascular system & hematology Diet High-Fat Diabetes Mellitus Experimental Random Allocation 03 medical and health sciences 0302 clinical medicine Stress Physiological Physical Conditioning Animal Physiology (medical) Diabetes mellitus medicine Animals In patient Rats Wistar Beneficial effects Heart Failure business.industry Heart medicine.disease Rats Disease Models Animal 030104 developmental biology Echocardiography Heart failure Physical therapy Energy Metabolism business Signal Transduction |
| Zdroj: | Journal of Applied Physiology. 123:1579-1591 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00117.2017 |
| Popis: | Exercise training has been demonstrated to have beneficial effects in patients with heart failure (HF) or diabetes. However, it is unknown whether diabetic patients with HF will benefit from exercise training. Male Wistar rats were fed either a standard (Sham, n = 53) or high-fat, high-sucrose diet ( n = 66) for 6 mo. After 2 mo of diet, the rats were already diabetic. Rats were then randomly subjected to either myocardial infarction by coronary artery ligation (MI) or sham operation. Two months later, heart failure was documented by echocardiography and animals were randomly subjected to exercise training with treadmill for an additional 8 wk or remained sedentary. At the end, rats were euthanized and tissues were assayed by RT-PCR, immunoblotting, spectrophotometry, and immunohistology. MI induced a similar decrease in ejection fraction in diabetic and lean animals but a higher premature mortality in the diabetic group. Exercise for 8 wk resulted in a higher working power developed by MI animals with diabetes and improved glycaemia but not ejection fraction or pathological phenotype. In contrast, exercise improved the ejection fraction and increased adaptive hypertrophy after MI in the lean group. Trained diabetic rats with MI were nevertheless able to develop cardiomyocyte hypertrophy but without angiogenic responses. Exercise improved stress markers and cardiac energy metabolism in lean but not diabetic-MI rats. Hence, following HF, the benefits of exercise training on cardiac function are blunted in diabetic animals. In conclusion, exercise training only improved the myocardial profile of infarcted lean rats fed the standard diet.NEW & NOTEWORTHY Exercise training is beneficial in patients with heart failure (HF) or diabetes. However, less is known of the possible benefit of exercise training for HF patients with diabetes. Using a rat model where both diabetes and MI had been induced, we showed that 2 mo after MI, 8 wk of exercise training failed to improve cardiac function and metabolism in diabetic animals in contrast to lean animals. |
| Databáze: | OpenAIRE |
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