Is there a Relationship between Chronic Bladder Dysfunction and Somatic Symptoms in other Body Regions? 2. An Experimental Neuroanatomical Approach
| Autor: | Richard A. Schmidt, Manabu Ishigooka, Jörg Schubert, Dirk-Henrik Zermann |
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| Rok vydání: | 2005 |
| Předmět: |
Central Nervous System
Male Pathology medicine.medical_specialty Cord Urology Central nervous system Autonomic Nervous System Rats Sprague-Dawley Diencephalon medicine Animals Trigone of urinary bladder business.industry Urinary Bladder Diseases Anatomy Spinal cord medicine.disease Herpesvirus 1 Suid Rats Autonomic nervous system medicine.anatomical_structure Autonomic Nervous System Diseases Nephrology Body region Urinary bladder disease business |
| Zdroj: | International Urology and Nephrology. 37:263-273 |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | Objective: Based on clinical description of associated dysfunctional symptoms in patients with non-neurogenic lower urinary tract dysfunction an experimental setup was created in order to investigate the neuroanatomical basis for the clinical phenomena observed.Methods: Using 24 male adult Sprague-Dawley rats for retrograde mapping of the spinal cord and brain, a pseudorabies virus (PRV) tracer was subsequently injected into four pertinent locations; (a) the trigone, (b) the masseter muscle (c) the forepaw and (d) the hindpaw.Results: PRV tracing demonstrated clearly overlapping of labeled areas in the brain stem, diencephalon and thoracic-lumbar cord, from all injection sites of the rats.Conclusion: There is a diffuse overlap within the brain stem and spinal cord, of autonomic innervation to peripheral tissues based on the presented animal experiments. The described autonomic network allows an understanding of the occurrence of symptoms in distant regions of the body associated to chronic bladder dysfunction. |
| Databáze: | OpenAIRE |
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