DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife

Autor:	Rebecca G. Reed, Judith E. Carroll, Anna L. Marsland, Stephen B. Manuck
Rok vydání:	2022
Předmět:	Male Aging Humans Female Cognitive Dysfunction Cell Biology DNA Methylation Neuropsychological Tests Epigenesis Genetic
Zdroj:	Aging. 14(23)
ISSN:	1945-4589
Popis:	DNA methylation-based (DNAm) measures of biological aging associate with increased risk of morbidity and mortality, but their links with cognitive decline are less established. This study examined changes over a 16-year interval in epigenetic clocks (the traditional and principal components [PC]-based Horvath, Hannum, PhenoAge, GrimAge) and pace of aging measures (Dunedin PoAm, Dunedin PACE) in 48 midlife adults enrolled in the longitudinal arm of the Adult Health and Behavior project (56% Female, baseline Age
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effb8384eee13ec48c227b356dbe8d7e https://pubmed.ncbi.nlm.nih.gov/36374219 Zobrazit plný text záznamu