Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease
| Autor: | Davide Rossi, Francesca Romana Mauro, Mara Riminucci, Alberto Biggi, Emanuele Nicolai, Fortunato Morabito, Luca Laurenti, Francesca Paoloni, Stephane Chauvie, Robert Foa, Angela Rago, Francesco Autore, Giuseppe Cimino, Andrea Gallamini, Massimo Gentile, Melissa Campanelli, Marta Coscia, Gianluca Gaidano, Gian Mauro Sacchetti, Anna Guarini, Marilena Bellò, Fabio Trastulli |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research Lymphoma Chronic lymphocytic leukemia Gastroenterology immune system diseases Neoplasms hemic and lymphatic diseases 80 and over Chronic Tomography Aged 80 and over medicine.diagnostic_test Medicine (all) leukemia Adult Aged Combined Modality Therapy Female Follow-Up Studies Hodgkin Disease Humans Leukemia Lymphocytic Chronic B-Cell Lymphoma Large B-Cell Diffuse Middle Aged Neoplasm Staging Neoplasms Second Primary Positron-Emission Tomography Prognosis Retrospective Studies Survival Rate Tomography X-Ray Computed Hematology Anesthesiology and Pain Medicine Diffuse Lymphocytic X-Ray Computed Leukemia Second Primary Oncology PET progressive disease medicine.medical_specialty Standardized uptake value Internal medicine Biopsy Large B-Cell medicine Survival rate PET-CT business.industry B-Cell medicine.disease Settore MED/15 - MALATTIE DEL SANGUE business Nuclear medicine Progressive disease CLL |
| Popis: | In order to evaluate the predictive value of positron emission tomography-computed tomography (PET/CT) in discriminating the presence of a Richter's syndrome (RS) or a second malignancy (SM), as well as to evaluate its prognostic value in patients with chronic lymphocytic leukemia (CLL), we retrospectively analyzed the data of 90 patients who, in the suspicion of a RS or a SM, underwent PET/CT followed by the biopsy of the involved tissue. The median maximum Standardized Uptake Value (SUV max) in the presence of a CLL/small lymphocytic lymphoma, a diffuse large B-cell lymphoma (DLBCL), a Hodgkin lymphoma (HL), a SM were 3.5, 14.6, 7.0 and 6.3, respectively (P ⩽ 0.0001). A SUV max cutoff value ⩾ 5 showed a sensitivity, specificity, positive and negative predictive values of 88.2, 71.2, 51.3 and 94%, respectively, for the presence of a more aggressive disease (DLBCL, HL and SM). A SUV max ⩾ 5 identified also a subset of treatment naive patients with an inferior progression-free survival (P = 0.011) and overall survival (P = 0.067). These findings suggest that PET/CT may helpfully integrate the biologically-based prognostic stratification of CLL. Prospective clinical trials including larger cohorts of patients are needed to conclusively define the role and prognostic impact of PET/CT in the routine management of CLL patients. |
| Databáze: | OpenAIRE |
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