Microbiological, lipid and immunological profiles in children with gingivitis and type 1 diabetes mellitus
| Autor: | Rebeca De Souza Azevedo, Gláucia Schuindt Teixeira, Gabriela Alessandra da Cruz Galhardo Camargo, Natália Leal Vizoto, Flávia Sammartino Mariano, Mariana Ferreira Dib João, Renata O. Mattos-Graner, Cristiane Duque, Thamiris Santana Machado, Natália Helena Colombo |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Estadual de Campinas (UNICAMP), Universidade Federal Fluminense (UFF) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Periodontium Interleukin-1beta Dentistry Gastroenterology Gingivitis 0302 clinical medicine Diabetes mellitus Child Children biology Campylobacter rectus Polymerase chain reaction Cholesterol Cytokines Female Periodontal Index medicine.symptom Capnocytophaga Brazil medicine.medical_specialty Adolescent Enzyme-Linked Immunosorbent Assay 030209 endocrinology & metabolism Statistics Nonparametric 03 medical and health sciences stomatognathic system Internal medicine medicine Humans Tooth Deciduous General Dentistry Triglycerides Type 1 diabetes Interleukin-6 Tumor Necrosis Factor-alpha business.industry Capnocytophaga ochracea Original Articles 030206 dentistry medicine.disease biology.organism_classification Red complex Dentition Permanent lcsh:RK1-715 Diabetes Mellitus Type 1 lcsh:Dentistry Fusobacterium nucleatum business |
| Zdroj: | Journal of Applied Oral Science v.25 n.2 2017 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science, Volume: 25, Issue: 2, Pages: 217-226, Published: APR 2017 Journal of Applied Oral Science, Vol 25, Iss 2, Pp 217-226 Journal of Applied Oral Science Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1678-7757 |
| Popis: | Made available in DSpace on 2018-11-26T17:24:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01. Added 1 bitstream(s) on 2019-10-09T18:26:38Z : No. of bitstreams: 1 S1678-77572017000200217.pdf: 199895 bytes, checksum: 0912d4979dd7e9af0e4d346708df9943 (MD5) Objective: The aim of this study was to compare the prevalence of periodontal pathogens, systemic inflammatory mediators and lipid profiles in type 1 diabetes children (DM) with those observed in children without diabetes (NDM), both with gingivitis. Material and methods: Twenty-four DM children and twenty-seven NDM controls were evaluated. The periodontal status, glycemic and lipid profiles were determined for both groups. Subgingival samples of periodontal sites were collected to determine the prevalence of periodontal microorganisms by PCR. Blood samples were collected for IL-1-beta, TNF-alpha. and IL-6 analysis using ELISA kits. Results: Periodontal conditions of DM and NDM patients were similar, without statistical differences in periodontal indices. When considering patients with gingivitis, all lipid parameters evaluated were highest in the DM group; Capnocytophaga sputigena and Capnocytophaga ochracea were more prevalent in the periodontal sites of DM children. Red complex bacteria were detected in few sites of DM and NDM groups. Fusobacterium nucleatum and Campylobacter rectus were frequently found in both groups. Similar levels of IL-1-beta, TNF-alpha. and IL-6 were detected in DM and NDM children. Conclusion: Clinical and immunological profiles are similar between DM and NDM children. The presence of Capnocytophaga sputigena and Capnocytophaga ochracea were associated with gingivitis in DM children. Univ Estadual Paulista, Fac Odontol Aracatuba, Dept Odontol Infantil & Social, Rua Jose Bonifacio 1193, BR-16015050 Sao Paulo, Brazil Univ Estadual Campinas, Fac Odontol Piracicaba, Dept Diagnost Oral, Sao Paulo, Brazil Univ Fed Fluminense, Fac Odontol Nova Friburgo, Rio De Janeiro, Brazil Univ Estadual Paulista, Fac Odontol Aracatuba, Dept Odontol Infantil & Social, Rua Jose Bonifacio 1193, BR-16015050 Sao Paulo, Brazil |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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