Mapping hepatic blood oxygenation by quantitative BOLD (qBOLD) MRI
| Autor: | Kyong Tae Bae, Andrea He, Kenneth Wengler, Serter Gumus, Chuan Huang, Jinhong Wang, Xiang He, Mario Serrano Sosa, Shahid M. Hussain |
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| Rok vydání: | 2019 |
| Předmět: |
Treatment response
medicine.medical_specialty Blood volume 030218 nuclear medicine & medical imaging 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Internal medicine medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Oxygen saturation (medicine) business.industry Hemodynamics Venous blood Oxygenation Hypoxia (medical) Magnetic Resonance Imaging Healthy Volunteers Oxygen Liver Blood Volume Fraction Calibration Blood oxygenation Cardiology medicine.symptom business Monte Carlo Method Algorithms 030217 neurology & neurosurgery |
| Zdroj: | Magnetic Resonance in Medicine. 81:3272-3282 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.27642 |
| Popis: | Purpose Abnormalities in hepatic oxygen delivery and oxygen consumption may serve as a significant indicator of hepatic cellular dysfunction and may predict treatment response. However, conventional and oxygen-enhanced hepatic BOLD MRI can only provide semiquantitative assessment of hepatic oxygenation. Methods A hepatic quantitative BOLD (qBOLD) model was proposed for noninvasive mapping of hepatic venous blood oxygen saturation (Yv ) and deoxygenated blood volume (DBV) in human subjects. The validity and the estimation bias of the proposed model were evaluated by Monte Carlo simulations. Eight healthy subjects were scanned after written consent with institutional review board approval. Results Monte Carlo simulations demonstrated that the proposed single-compartment hepatic qBOLD model leads to significant deviation of the predicted T2 * decay profile from the simulated signal due to high hepatic blood volume fraction. Small relative estimation bias for hepatic Yv and significant overestimation for hepatic DBV were observed, which can be corrected by applying the calibration curves established from simulations. After correction, the mean hepatic Yv in human subjects was 56.8 ± 6.8%, and the mean hepatic DBV was 0.190 ± 0.035, consistent with measurements from other invasive approaches. Except in regions with significant vascular contamination, the maps for hepatic Yv and DBV were relatively homogenous. Conclusions With estimation bias correction, the hepatic qBOLD approach enables noninvasive mapping of hepatic blood volume and oxygenation in human subjects. The established protocol may be used to quantitatively assess hepatic tissue hypoxia in multiple liver diseases. |
| Databáze: | OpenAIRE |
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