The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
| Autor: | Judith Salvage-Jones, Christian Cobbold, Kelly J Hitchens, Robert B. Ashman, David A. Hume, Jennifer L. Stow, Suzanne Butcher, Silvia Manzanero, Kate Schroder, Anthony G Beckhouse, Peter Sobieszczuk, Lauren Stewart, Bo Ma, Xin Li, Sally Orr, Rachael Z. Murray, Christine A. Wells, Yu-Lan-Sandra Lo, Helen Blanchard, Daniel Lebus |
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| Rok vydání: | 2008 |
| Předmět: |
Phagocytic cup
Immunology Biology Microbiology Cell Line Mice Phagocytosis Immunity Phagosomes Candida albicans medicine Immunology and Allergy Macrophage Animals Humans Lectins C-Type Mice Knockout Mice Inbred BALB C Innate immune system Tumor Necrosis Factor-alpha Macrophages Candidiasis biology.organism_classification medicine.disease Corpus albicans Immunity Innate Toll-Like Receptor 2 Cell biology Mice Inbred C57BL Tumor necrosis factor alpha Systemic candidiasis Disease Susceptibility |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 180(11) |
| ISSN: | 0022-1767 |
| Popis: | The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-α by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection. |
| Databáze: | OpenAIRE |
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