Immunohistochemical Characterization of Bcl-2 in Oral Potentially Malignant Disorders
| Autor: | E. Padin-Iruegas, Irene Lafuente-Ibáñez de Mendoza, Cintia Chamorro-Petronacci, Andrés Blanco-Carrión, Alejandro I. Lorenzo-Pouso, José M. Suárez-Peñaranda, Karem López Ortega, Mario Pérez-Sayáns |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Epithelial dysplasia Histology Cellular homeostasis Gastroenterology Pathology and Forensic Medicine Malignant transformation Internal medicine medicine Humans Oral mucosa Aged Retrospective Studies Aged 80 and over business.industry Mouth Mucosa Odds ratio Middle Aged medicine.disease Immunohistochemistry stomatognathic diseases Medical Laboratory Technology Cell Transformation Neoplastic medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Female Mouth Neoplasms Oral lichen planus business Precancerous Conditions Oral medicine |
| Zdroj: | Applied Immunohistochemistry & Molecular Morphology. 29:706-712 |
| ISSN: | 1541-2016 |
| DOI: | 10.1097/pai.0000000000000945 |
| Popis: | Bcl-2 is a group of apoptotic proteins that play a key role in cellular homeostasis. Overexpression of Bcl-2 has been associated with the poor prognosis of oral squamous cell carcinoma (OSCC). The aim of this study is to analyze the immunohistochemical expression of Bcl-2 in healthy oral mucosa, different oral potentially malignant disorders and OSCC, and to determine its diagnostic value. A retrospective observational study was carried out in the Oral Medicine Unit of the University of Santiago de Compostela. All the clinicopathologic data were collected and paraffin-embedded blocks were available to perform the immunohistochemistry study with Bcl-2. We studied 18 fibromas, 15 OSCC, 29 oral leukoplakia lesions (OL), 59 oral lichen planus (OLP) cases, and 16 healthy controls. OL with epithelial dysplasia (31.2%) showed the highest expression of Bcl-2 and OLP (1.9%) showed the lowest expression of Bcl-2 (P=0.025). Receiver operating characteristics curves showed that the detection of Bcl-2 enables discrimination between OL and OLPs (sensitivity: 58.6%, specificity of 99.32%). Bcl-2 negative expression in the OLP diagnosis obtained an odds ratio of 13.750 (95% confidence interval: 3.354-56.369; P |
| Databáze: | OpenAIRE |
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