Hyperactivation of the cognitive control network in cocaine use disorders during a multisensory Stroop task
| Autor: | Josef M. Ling, Andrew R. Mayer, Zhen Yang, Claire E. Wilcox, Terri M. Teshiba |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Prefrontal Cortex Audiology Toxicology Brain mapping Article Cocaine-Related Disorders Cognition Thalamus Reaction Time medicine Humans Pharmacology (medical) Prefrontal cortex Pharmacology Brain Mapping Hyperactivation medicine.diagnostic_test medicine.disease Corpus Striatum Drug Abstinence Substance abuse Psychiatry and Mental health Case-Control Studies Stroop Test Female Functional magnetic resonance imaging Psychology Stroop effect Cognitive psychology |
| Zdroj: | Drug and Alcohol Dependence. 133:235-241 |
| ISSN: | 0376-8716 |
| Popis: | It has been suggested that individuals with cocaine use disorders (chronic cocaine abusers, CCA) have impairments in cognitive control, which likely contribute to impairments in decision making around drug use and relapse. However, deficits in cognitive control have currently only been studied under conditions of unisensory stimulation, which may not be reflective of more realistic multisensory drug cues.The current study employed functional magnetic resonance imaging (fMRI) to measure neuronal activity during a multisensory numeric Stroop task.Despite few differences in reaction time, recently abstinent CCA (N=14) exhibited increased activation in prefrontal cortex, striatum and thalamus during cognitive control relative to a group of carefully matched controls (N=16). Importantly, these neuronal differences were relatively robust in classifying patients from controls (approximately 90% accuracy) and evident during conditions of both low (slow stimulus presentation rate) and relatively high (faster stimulus presentation rate) cognitive demand. In addition, CCA also failed to deactivate the default-mode network during high frequency visual trials.In summary, current results indicate compensatory activation within the cognitive control network in recently abstinent CCA to achieve similar levels of behavioral performance. |
| Databáze: | OpenAIRE |
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