Mice with diverse microbial exposure histories as a model for preclinical vaccine testing
| Autor: | David K. Meyerholz, J. Michael Stolley, Hezkiel Nanda, Clayton K. Mickelson, Frances K. Shepherd, Sathi Wijeyesinghe, Vaiva Vezys, Sara E. Hamilton, Mark Pierson, Steven S. Shen, Ryan A. Langlois, Jessica K. Fiege, David Masopust, Katharine E. Block, William E. Matchett |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Mice Inbred BALB C Vaccination Biology Microbiology Immunity Humoral Mice Inbred C57BL Mice Immunogenicity Vaccine Immune system Vaccine Immunogenicity Poor control Influenza Vaccines Immunity Virology Immunology Humoral immunity Post vaccination Vaccine Testing Animals Humans Female Parasitology Spotlight |
| Zdroj: | Cell Reports Medicine |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2021.10.001 |
| Popis: | Summary In a recent issue of Cell Host and Microbe, Fiege and colleagues1 report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses. In a recent issue of Cell Host and Microbe, Fiege and colleagues1 report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses. |
| Databáze: | OpenAIRE |
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