Suppression of host PTEN gene expression for Leishmania donovani survival in Indian visceral leishmaniasis
| Autor: | Bhawana Singh, Shyam Sundar, Jaya Chakravarty, Toolika Singh, Medhavi Sudarshan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Immunology Phosphatase Leishmania donovani EGR1 Down-Regulation Gene Expression Microbiology Article 03 medical and health sciences Gene expression medicine Humans PTEN Gene Immune Evasion 030102 biochemistry & molecular biology biology PTEN Phosphohydrolase medicine.disease biology.organism_classification Leishmania 030104 developmental biology Infectious Diseases Visceral leishmaniasis biology.protein Cancer research Leishmaniasis Visceral |
| Zdroj: | Microbes and Infection. 18:369-372 |
| ISSN: | 1286-4579 |
| DOI: | 10.1016/j.micinf.2015.12.008 |
| Popis: | Lipid phosphatase, PTEN is amongst the host gene actively involved in determining disease susceptibility. Expression of pten and other genes in vicinity egr1 & 4e-bp1 were evaluated in splenic tissue before and after treatment in visceral leishmaniasis patients. Lower expression of egr1 in correlation with pten suppressed 4e-bp1 gene in active cases. The higher levels of pten mRNA expression post treatment confirmed its role in effective clearance of Leishmania . Therefore, it is hypothesized that lower mRNA expression of pten is due to suppression of egr1 activates PI3K signaling bestowing host the ability to cope up infection and continue its normal metabolic machinery. |
| Databáze: | OpenAIRE |
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