Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis

Autor: Erik Simonsen, Jan Olav Johannessen, Kristin Lie Romm, Tor K. Larsen, Johannes Langeveld, Svein Friis, Bjørn Rishovd Rund, Julie Evensen, Helene Eidsmo Barder, Wenche ten Velden Hegelstad, Jan Ivar Røssberg, Inge Joa, U. Haahr, Per Vaglum, Stein Opjordsmoen, Thomas H. McGlashan, Erlend Strand Gardsjord, Ingrid Melle
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Quality of Life/psychology
Alcohol abuse
Hostility
Personal Satisfaction
0302 clinical medicine
Quality of life
Longitudinal Studies
Young adult
Non-U.S. Gov't
Research Support
Non-U.S. Gov't
Middle Aged
Psychiatry and Mental health
Schizophrenia
Regression Analysis
Life satisfaction
Female
Biological psychiatry
medicine.symptom
Clinical psychology
Adult
medicine.medical_specialty
Psychosis
First episode psychosis
Adolescent
Remission
Research Support
N.I.H
03 medical and health sciences
Young Adult
Research Support
N.I.H.
Extramural
Internal medicine
medicine
Journal Article
Humans
Long-term follow-up
Biological Psychiatry
Aged
Psychiatric Status Rating Scales
Analysis of Variance
business.industry
Extramural
medicine.disease
Psychotic Disorders/psychology
030227 psychiatry
Psychotic Disorders
business
030217 neurology & neurosurgery
Zdroj: Schizophrenia Research, 193, 364. Elsevier
ISSN: 0920-9964
Popis: Background Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status. Methods Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed. QoL was assessed by Lehman's Quality of Life Interview. Remission was defined according to criteria proposed by the Remission in Schizophrenia Working Group. One-way ANOVA, mixed model analysis, bivariate correlations and multiple regression analyses were performed. Results Patients going into stable symptomatic remission showed a more positive S-QoL-development over the follow-up period and reported higher life satisfaction at 10-year follow-up compared to non-remission. At 10-year follow-up, depressive symptoms and alcohol abuse or dependence explained a significant amount of variance in S-QoL among patients in remission. Among patients in non-remission, PANSS excitative component explained a significant amount of variance in S-QoL. All significant effects were negative. Conclusions Stable symptomatic remission is associated with a more positive development of overall life satisfaction. Furthermore, different symptoms influence life satisfaction depending on status of remission. This has important clinical implications. While patients in remission might need treatment for depressive symptoms to increase S-QoL, in non-remission measures aiming to decrease hostility and uncooperativeness should be part of the treatment approach. Alcohol problems should be treated regardless of remission status.
Databáze: OpenAIRE
Externí odkaz: