Role of Prostaglandins, -Adrenoceptors, and the Central Nervous System in the Control of Renin Release in Conscious Sodium-Depleted Rats
| Autor: | Ernesto L. Schiffrin, Roger Boucher, Raul Garcia, Jacques Genest, Jolanta Gutkowska |
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| Rok vydání: | 1980 |
| Předmět: |
Central Nervous System
Male Indomethacin Central nervous system Propranolol Pharmacology Kidney Plasma renin activity Clonidine General Biochemistry Genetics and Molecular Biology Receptors Adrenergic beta Renin Renin–angiotensin system medicine Animals Receptor Chemistry Rats Receptors Adrenergic medicine.anatomical_structure Prostaglandins Systemic administration Drug Therapy Combination Hyponatremia medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 165:151-154 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-165-40951 |
| Popis: | The interrelationship of prostaglandins, β-adrenoceptors, and the central nervous system in the control of renin release in conscious sodium-depleted rats was investigated by acute pharmacologic blockade with systemic administration of indomethacin and propranolol and intracerebroventricular injection of clonidine. Indomethacin and propranolol lowered plasma renin activity significantly with respect to control. When both were administered to the same experimental animals, their renin-lowering effect was additive. Intracerebroventricular clonidine and intraperitoneal propranolol or the injection of both produced a similar renin-lowering effect on sodium-depleted rats. It is concluded that the central nervous system, through an α-adrenergic pathway peripherally mediated by β-adrenergic receptors, plays an important role in the renin release in the conscious sodium-depleted rat. A prostaglandin-mediated pathway is also involved in the renin response to the sodium-depleted state, acting in parallel to... |
| Databáze: | OpenAIRE |
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