Pharmacokinetics of prenalterol in healthy subjects and patients with congestive heart failure
| Autor: | O. Rönn |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Metabolic Clearance Rate Administration Oral Biological Availability Pharmacology Pharmacokinetics Oral administration Internal Medicine Humans Medicine Infusions Parenteral Practolol Heart Failure Meal Prenalterol business.industry Adrenergic beta-Agonists medicine.disease Controlled release Bioavailability Delayed-Action Preparations Heart failure Renal physiology Anesthesia business Half-Life medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 211:89-98 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1982.tb00838.x |
| Popis: | 1. Prenalterol is rapidly and completely absorbed after oral administration with peak concentrations reached after 30 minutes. 2. Prenalterol is rapidly distributed to extravascular tissues after intravenous administration. 3. The extent of bioavailability after administration of prenalterol as a solution is about 25% of an intravenous dose. After administration of 20 mg prenalterol in a controlled release preparation the bioavailability is increased to about 45%. 4. The half–life of the elimination phase is close to 2 hours. 5. 60% of an intravenous dose and 15% of an oral dose is eliminated unchanged by renal excretion. The rest is mainly excreted as the sulphate ester of prenalterol. This presentation deals with the pharmacokinetic properties of prenalterol. The results have been obtained mainly from studies in healthy subjects after acute administration of the drug both intravenously and orally, but some preliminary data on the pharmacokinetics of prenalterol In patients with cardiac failure will also be presented. The studies were performed in six healthy male volunteers 22 to 25 years of age and with a mean weight of 78 kg. The subjects were in good health as judged from clinical and laboratory examinatlons. Prenalterol was administered on occasions separated by at least three days and was given in a randomised order. The subjects arrived at the laboratory after having fasted overnight. A standardised meal was given 3 and 6 hours after drug administration. Prenalterol was administered as prenalterol hydrochloride, a salt freely soluble In water. A single dose of 2.5 mg prenalterol was infused intravenously over 5 min. Oral prenalterol was given as a solution together with 100 ml of water in doses of 2.5, 5.0 and 10.0 mg. Three of the subjects received the intravenous dose and the oral dose of 2.5 mg as tritiated compound. |
| Databáze: | OpenAIRE |
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