How to Manage Synchronous Endometrial and Ovarian Cancer Patients?
Autor: | Myong Cheol Lim, Wonkyo Shin, Sokbom Kang, Sang Soo Seo, Sang Yoon Park |
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Rok vydání: | 2020 |
Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Multivariate analysis genetic structures Kaplan-Meier Estimate Disease-Free Survival Metastasis Neoplasms Multiple Primary 03 medical and health sciences Young Adult 0302 clinical medicine Surgical oncology Ovarian cancer Internal medicine Genetics medicine Adjuvant therapy Humans RC254-282 Aged Retrospective Studies Ovarian Neoplasms Univariate analysis Analysis of Variance 030219 obstetrics & reproductive medicine business.industry Medical record Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged medicine.disease Prognosis Endometrial Neoplasms 030220 oncology & carcinogenesis Lymphatic Metastasis Female Neoplasm Grading Neoplasm Recurrence Local business Synchronous cancer Research Article |
Zdroj: | BMC Cancer BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021) |
Popis: | Backgrounds We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC). Methods The medical records of 47 patients diagnosed synchronously with endometrial and ovarian cancer between January 2006 and December 2018 were retrospectively reviewed. Twenty-eight and 19 patients were diagnosed with DPC and MC, respectively. Demographics, recurrence-free survival (RFS), and 5-year overall survival (OS) were compared. The clinical factors affecting survival were evaluated using univariate and multivariate analyses. Results The demographics were not different between both groups. Endometrioid histology and the International Federation of Gynecology and Obstetrics grade were higher in the MC group than in the DPC group (42.1% vs. 10.7%; P = 0.018, P = 0.002, respectively). The ratio of post-operative adjuvant therapy was not different in both groups. Recurrence occurred in five patients with DPC and seven with MC. The difference in RFS was not significantly different (P = 0.131) but the OS was different between both groups (P = 0.020). Histology and para-aortic lymph node metastasis were associated wtih RFS in univariate analysis, but no difference was found in multivariate analysis. Conclusions Although DPC patients had longer OS, multivariate analysis did not identify any influential factors. Focus should be placed on defining the appropriate adjuvant treatment for high-risk patients, which will improve prognosis, rather than on discriminating between DPC and MC. |
Databáze: | OpenAIRE |
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