Biomarkers in premature calves with and without respiratory distress syndrome
| Autor: | Murat Kaan Durgut, Merve Ider, Muhammed M. Kapar, Tuğba Melike Parlak, Alper Ertürk, Kamil Uney, Amir Naseri, Nimet Ismailoglu, Mahmut Ok |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
Veterinary medicine Physiology Standard Article FOOD AND FIBER premature calf Tachypnea chemistry.chemical_compound pulmonary hypertension SF600-1100 Medicine Animals RDS Lung Respiratory Distress Syndrome Newborn General Veterinary Respiratory distress business.industry Infant Newborn Hypoxia (medical) respiratory system medicine.disease Pulmonary Surfactant-Associated Protein D Pulmonary hypertension respiratory tract diseases chemistry endothelial biomarkers Respiratory Arterial blood Base excess Cattle medicine.symptom business Asymmetric dimethylarginine Hypercapnia Biomarkers pulmonary epithelium |
| Zdroj: | Journal of Veterinary Internal Medicine, Vol 35, Iss 5, Pp 2524-2533 (2021) Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 1939-1676 |
| Popis: | Background Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung‐specific epithelial and endothelial biomarkers are needed. Objective To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RDS) by using lung‐specific epithelial and endothelial biomarkers and determine the prognostic value of these markers in premature calves. Animals Fifty premature calves with RDS, 20 non‐RDS premature calves, and 10 healthy term calves. Methods Hypoxia, hypercapnia, and tachypnea were considered criteria for RDS. Arterial blood gases (PaO2, PaCO2, oxygen saturation [SO2], base excess [BE], and serum lactate concentration) were measured to assess hypoxia. Serum concentrations of lung‐specific growth differentiation factor‐15 (GDF‐15), asymmetric dimethylarginine (ADMA), endothelin‐1 (ET‐1), vascular endothelial growth factor (VEGF), and surfactant protein D (SP‐D) were measured to assess PAH. Results Arterial blood pH, PaO2, SO2, and BE of premature calves with RDS were significantly lower and PaCO2 and lactate concentrations higher compared to non‐RDS premature and healthy calves. The ADMA and SP‐D concentrations of premature calves with RDS were lower and serum ET‐1 concentrations higher than those of non‐RDS premature and healthy calves. No statistical differences for GDF‐15 and VEGF were found among groups. Conclusions and Clinical Importance Significant increases in serum ET‐1 concentrations and decreases in ADMA and SP‐D concentrations highlight the utility of these markers in the diagnosis of PAH in premature calves with RDS. Also, we found that ET‐1 was a reliable diagnostic and prognostic biomarker for PAH and predicting mortality in premature calves. |
| Databáze: | OpenAIRE |
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