Circuitry Rewiring Directly Couples Competence to Predation in the Gut Dweller Streptococcus salivarius
| Autor: | Andrea Sass, Catherine Nannan, Jacques Mahillon, Pascal Hols, Johann Mignolet, Tom Coenye, Laetitia Fontaine |
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| Přispěvatelé: | UCL - SST/ISV - Institut des sciences de la vie |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bacillus subtilis THERMOPHILUS medicine.disease_cause Bacteriocins Gene Regulatory Networks TRANSCRIPTION FACTOR Promoter Regions Genetic lcsh:QH301-705.5 cell-cell communication Genetics biology QUORUM-SENSING REGULATION Horizontal gene transfer RNPP competence bacteriocin production 030106 microbiology Genetics and Molecular Biology Regulon Streptococcus salivarius General Biochemistry Genetics and Molecular Biology Article BACILLUS-SUBTILIS MECHANISMS NATURAL TRANSFORMATION 03 medical and health sciences Bacteriocin Bacterial Proteins Species Specificity LATERAL GENE-TRANSFER Streptococcus pneumoniae medicine Amino Acid Sequence BACTERIAL TRANSFORMATION Base Sequence Biology and Life Sciences streptococcus Pathogenic bacteria biology.organism_classification Streptococcus mutans Gastrointestinal Tract Transformation (genetics) lcsh:Biology (General) Genes Bacterial Bacterial Translocation General Biochemistry PNEUMONIAE PEPTIDE PHEROMONE transcriptional network |
| Zdroj: | CELL REPORTS Cell Reports, Vol 22, Iss 7, Pp 1627-1638 (2018) Cell Reports, Vol. 22, no.7, p. 1627-1638 (2018) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Small distortions in transcriptional networks might lead to drastic phenotypical changes, especially in cellular developmental programs such as competence for natural transformation. Here, we report a pervasive circuitry rewiring for competence and predation interplay in commensal streptococci. Canonically, in streptococci paradigms such as Streptococcus pneumoniae and Streptococcus mutans, the pheromone-based two-component system BlpRH is a central node that orchestrates the production of antimicrobial compounds (bacteriocins) and incorporates signal from the competence activation cascade. However, the human commensal Streptococcus salivarius does not contain a functional BlpRH pair, while the competence signaling system ComRS directly couples bacteriocin production and competence commitment. This network shortcut might underlie an optimal adaptation against microbial competitors and explain the high prevalence of S. salivarius in the human digestive tract. Moreover, the broad spectrum of bacteriocin activity against pathogenic bacteria showcases the commensal and genetically tractable S. salivarius species as a user-friendly model for competence and bacterial predation. |
| Databáze: | OpenAIRE |
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