A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear
| Autor: | Vicente Moreno, Francisco J. Espinós, Luis Felipe del Castillo, Marcel Aguilella-Arzo, Roxana M. del Castillo |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Pelicula lagrimal Oxygen flux Flow (psychology) Lentes de contacto chemistry.chemical_element Context (language use) Oxygen consumption rate PRODUCCION ANIMAL Oxygen Tear film Cornea 03 medical and health sciences 0302 clinical medicine Oxygen Consumption Corneal hypoxia Flujo de oxígeno medicine Humans Hipoxia Monod kinetics model Oxygen tension Modelo cinético monod Tension de oxígeno Partial pressure Contact lens Contact Lenses Hydrophilic eye diseases Córnea medicine.anatomical_structure chemistry Lens (anatomy) Tears MAQUINAS Y MOTORES TERMICOS 030221 ophthalmology & optometry Tasa de consumo de oxígeno sense organs 030217 neurology & neurosurgery Optometry Biomedical engineering |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1989-1342 |
| Popis: | [EN] The study of oxygen consumption rate under¿ in vivo¿ human cornea during contact lens wear has been technically a challenge and several attempts have been made in the last 20 years to model the physiology of the human cornea during contact lens wear. Unfortunately, some of these models, based on a constant corneal oxygen consumption rate, produce areas on the cornea where the oxygen tension is negative, which has no physical sense. In order to avoid such inconsistency, different researchers have developed alternative models of oxygen consumption, which predict the likely oxygen metrics available at the interface cornea/post lens tear film by determination of oxygen flux, oxygen consumption, and oxygen tension through the different layers (endothelium, stroma, and epithelium). Although oxygen deficiency produces corneal edema, corneal swelling, hypoxia, acidosis, and other abnormalities, the estimation of the oxygen distribution below the impact of a contact lens wear is interesting to know which lens transmissibility was adequate to maintain the cornea and avoid epithelial and stromal anoxia. The estimation of minimum transmissibility for a lens for extended wear applications will be very useful for both clinicians and manufacturers. The aim of this work is to present a complete discussion based on Monod kinetics model that permits give an estimation of oxygen partial pressure distribution, the profile distribution of corneal flux and oxygen consumption rate, and finally the estimation of the relaxation mechanism of the cornea depending on the oxygen tension at the interface cornea/post lens tear film. Relaxation time in this context can quantify the capability of the corneal tissue to adapt to increasing concentrations of oxygen. It is proposed this parameter as a biological meaningful indicator of the interaction between contact lens polymers and living tissues such as the corneal cellular layer. This work was supported by the Government of Spain (project no. PID2019-108434GB-100 AEI/FEDER,UE), and Universitat Jaume I (project no. UJI-B2018-53). This research was funded by DGTIC-UNAM, with access to the Miztli-UNAM supercomputer, with the project LANCADUNAM-DGTIC-055. This work was supported by UNAM-PAPIIT projects IG 100618, IG 114818, IN114318, IN120120.The authors want to thank Alberto López, Cain González, Alejandro Pompa, and Alan Ortega for technical help. |
| Databáze: | OpenAIRE |
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