Application of Tandem Dispersive Liquid–Liquid Microextraction as an Efficient Method for Preconcentration of Two Antidepressant Drugs in Real Samples Combined with High Performance Liquid Chromatography
| Autor: | Bahare Arabkhani, Ghadamali Bagherian, Nasser Goudarzi, Mansour Arab Chamjangali |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Analyte Aqueous solution Chromatography Tandem Liquid Phase Microextraction Chemistry 010401 analytical chemistry Extraction (chemistry) 02 engineering and technology General Medicine 021001 nanoscience & nanotechnology 01 natural sciences High-performance liquid chromatography Antidepressive Agents 0104 chemical sciences Analytical Chemistry Ionic strength Solvents Liquid liquid 0210 nano-technology Chromatography High Pressure Liquid Water Pollutants Chemical |
| Zdroj: | Journal of Chromatographic Science. 60:96-103 |
| ISSN: | 1945-239X 0021-9665 |
| DOI: | 10.1093/chromsci/bmab038 |
| Popis: | In the present work, tandem dispersive liquid–liquid microextraction (TDLLME) coupled with liquid chromatography was used for the determination of the two antidepressant drugs citalopram (CIT) and sertraline (SER) in complicated matrices. Indeed, the present approach was used to improve the suitability and appropriateness of the dispersive liquid–liquid microextraction (DLLME) method in complicated matrices. Firstly, 10 mL of the sample solution containing the two understudied drugs was extracted into an organic solvent (200 μL of 1,2-dichloromethane) using the DLLME method. Then the extracted analytes were back-extracted into 100 μL of an aqueous acceptor phase. The total extraction time of this method is about 6 min. To achieve the best efficiency for this method, efficient parameters like the kind and volume of the organic solvent and the effect of the ionic strength on the effectiveness of extraction were reviewed and improved. Under the optimized experimental conditions, TDLLME showed good linearity in the range of 100.0–7000.0 ng mL−1. The limits of detection were found to be 10.0 ng mL−1 for CIT and 2.0 ng mL−1 for SER. The relative standard deviation (RSD) is obtained in the range of 0.7–4.1%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|