The neutrophil-to-lymphocyte ratio prechemotherapy and postchemotherapy as a prognostic marker in metastatic gastric cancer
| Autor: | Inho Kim, Sang Mi Ro, Sang Young Roh, Ji Hyun Yang, Joon Won Jeong, Jieun Lee, Hyunho Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Multivariate analysis Survival Neutrophils medicine.medical_treatment Stomach neoplasms Metastatic gastric cancer Prognostic score Hemato-Oncology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Lymphocyte Count Lymphocytes Neutrophil to lymphocyte ratio Aged Retrospective Studies Chemotherapy Univariate analysis business.industry fungi Hazard ratio Middle Aged Prognosis 030104 developmental biology 030220 oncology & carcinogenesis Female Original Article Drug therapy business Biomarkers |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 1226-3303 |
| Popis: | Background/Aims Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC). Methods We retrospectively reviewed the records of 502 patients who received first-line palliative chemotherapy for mGC between 2007 and 2013. The neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS) were assessed before and after chemotherapy to evaluate their association with survival. The NLR values were categorized into two groups based on a cut-off value of 3; mGPS values were classified as high versus low. Results High prechemotherapy NLR was significantly associated with poor overall survival on univariate analysis (p = 0.002). On multivariate analysis, high prechemotherapy NLR (hazard ratio, 1.43; p < 0.001) was an independent prognostic factor for poor overall survival. However, the prechemotherapy mGPS was not significantly associated with survival. Continuously high NLR or a shift to high NLR postchemotherapy was associated with poor chemotherapy response as well as survival, while NLR reduction was associated with a good response (linear by linear association, p < 0.001) and a favorable prognosis. Conclusions Prechemotherapy NLR can be used as a prognostic factor in mGC, while the postchemotherapy NLR value may predict the chemotherapeutic response and prognosis. In contrast, mGPS has limited prognostic utility in mGC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|