The effect of Cotinus coggygria L. ethanol extract in the treatment of burn wounds

Autor: Buşra ERTAŞ, Betül OKUYAN, Ali ŞEN, Feriha ERCAN, Hüseyin ÖNEL, Fatih GÖĞER, Göksel ŞENER
Přispěvatelé: Erta B., OKUYAN B., ŞEN A., ERCAN F., Onel H., GÖGER F., Sener G.
Rok vydání: 2022
Předmět:
burn wound healing activity
Farmakoloji
Life Sciences (LIFE)
Pharmacy
phenolic compounds
Sağlık Bilimleri
Antioxidant activity
Drug Guides
Cotinus coggygria
ANTIOXIDANT
Yaşam Bilimleri
Health Sciences
FARMAKOLOJİ VE ECZACILIK
IMPROVES
LEAVES
INJURY
Farmakoloji
Toksikoloji ve Eczacılık (çeşitli)
Pharmacology (medical)
General Pharmacology
Toxicology and Pharmaceutics
OXIDATIVE STRESS
anti-inflammatory activity
Eczacılık
PHARMACOLOGY & PHARMACY
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
Pharmacology
DAMAGE
PHARMACOLOGY & TOXICOLOGY
Temel Bilimler
Basic Pharmaceutics Sciences
Life Sciences
SCOP
PHENOLIC-COMPOUNDS
Pharmacology and Therapeutics
Genel Farmakoloji
Toksikoloji ve Eczacılık
Farmakoloji (tıbbi)
MEDICINAL-PLANTS
Temel Eczacılık Bilimleri
İlaç Rehberleri
Yaşam Bilimleri (LIFE)
Farmakoloji ve Toksikoloji
HEALING PROPERTIES
Natural Sciences
Zdroj: Journal of Research in Pharmacy. 26:554-564
ISSN: 2630-6344
Popis: The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2\"-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
Databáze: OpenAIRE
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