Menopause Is Associated with Accelerated Lung Function Decline
| Autor: | Sandra Suske, Jesús Martínez-Moratalla Rovira, Karl A. Franklin, Steinar Hustad, Francisco Gómez Real, Bénédicte Leynaert, Kai Triebner, Cecilie Svanes, Nicole Probst-Hensch, Deborah Jarvis, Isabelle Pin, Chantal Raherison, Eva Lindberg, Bryndis Benediktsdottir, Bobette Matulonga, José Luis Sánchez-Ramos, Luca Puggini, Vivi Schlünssen, Ane Johannessen, Mathias Holm, Shyamali C. Dharmage, Pascal Demoly, Joachim Heinrich, Rain Jögi, José Antonio Gullón Blanco, Jordi Sunyer, Judith Garcia-Aymerich, Nerea Muniozguren Agirre |
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| Přispěvatelé: | Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Centre d'Investigation Clinique [Grenoble] (CIC Grenoble), Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Michallon, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Grenoble] (CIC Grenoble ), CHU Grenoble-Hôpital Michallon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
SYSTEMIC INFLAMMATION
Aging Respiratory System Vital Capacity Physiology menopause Critical Care and Intensive Care Medicine [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Pulmonary function testing 0302 clinical medicine Forced Expiratory Volume Longitudinal Studies 030212 general & internal medicine Lung media_common education.field_of_study medicine.diagnostic_test Age Factors 11 Medical And Health Sciences Middle Aged Respiratory Function Tests 3. Good health Europe Menopause RESPIRATORY SYMPTOMS ESTROGEN medicine.anatomical_structure POSTMENOPAUSAL WOMEN Female HEALTH MENSTRUAL-CYCLE Life Sciences & Biomedicine TRANSITION Adult Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty media_common.quotation_subject Population sex hormones 03 medical and health sciences FEV1/FVC ratio Critical Care Medicine General & Internal Medicine Internal medicine Journal Article medicine latent class analysis Humans education Menstrual cycle Asthma Science & Technology business.industry lung function decline PULMONARY-FUNCTION medicine.disease Endocrinology 030228 respiratory system reproductive aging ASTHMA SEX-HORMONES business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2017, 195 (8), pp.1058-1065. ⟨10.1164/rccm.201605-0968OC⟩ Triebner, K, Matulonga, B, Johannessen, A, Suske, S, Benediktsdóttir, B, Demoly, P, Dharmage, S C, Franklin, K A, Garcia-Aymerich, J, Gullón Blanco, J A, Heinrich, J, Holm, M, Jarvis, D, Jõgi, R, Lindberg, E, Moratalla Rovira, J M, Muniozguren Agirre, N, Pin, I, Probst-Hensch, N, Puggini, L, Raherison, C, Sánchez-Ramos, J L, Schlünssen, V, Sunyer, J, Svanes, C, Hustad, S, Leynaert, B & Gómez Real, F 2017, ' Menopause Is Associated with Accelerated Lung Function Decline ', American Journal of Respiratory and Critical Care Medicine, vol. 195, no. 8, pp. 1058-1065 . https://doi.org/10.1164/rccm.201605-0968OC |
| ISSN: | 1073-449X 1535-4970 |
| Popis: | RATIONALE: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis and may impair lung function. Lung function decline has not previously been investigated in relation to menopause. OBJECTIVES: To study whether lung function decline, assessed by forced vital capacity and forced expiratory volume in one second, is accelerated in women who undergo menopause. METHODS: The population-based longitudinal European Community Respiratory Health Survey provided serum samples, spirometry and questionnaire data about respiratory and reproductive health from three study waves (N=1438). We measured follicle stimulating hormone and luteinizing hormone and added information on menstrual patterns, to determine menopausal status using latent class analysis. Associations with lung function decline were investigated using linear mixed effects models, adjusting for age, height, weight, packyears, current smoking, age at completed full-time education, spirometer and including study center as random effect. MEASUREMENTS AND MAIN RESULTS: Menopausal status was associated with accelerated lung function decline. The adjusted mean forced vital capacity decline was increased by -10.2 ml/yr (95% Confidence interval -13.1 to -7.2) in transitional women and -12.5 ml/yr (-16.2 to -8.9) in postmenopausal women, compared to women menstruating regularly. The adjusted mean forced expiratory volume in one second decline increased by -3.8 ml/yr (-6.3 to -2.9) in transitional women and -5.2 ml/yr (-8.3 to -2.0) in postmenopausal women. CONCLUSIONS: Lung function declined more rapidly among transitional and postmenopausal women, in particular for forced vital capacity, beyond the expected age change. Clinicians should be aware that respiratory health often deteriorates during reproductive aging. |
| Databáze: | OpenAIRE |
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