Selective breeding for intravenous drug self-administration in rats: a pilot study
| Autor: | Shuangteng He, Deepan Mathur, Yungao Yang, Kenneth Grasing |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Drugs of abuse
Future studies Physiology Pilot Projects Self Administration Breeding Selective breeding Cocaine Medicine Animals Anesthetics Local Rats Wistar Infusions Intravenous Substance Abuse Intravenous Pharmacology Intravenous drug Behavior Animal business.industry medicine.disease Rats Substance abuse Psychiatry and Mental health Morphine Conditioning Operant business Self-administration Reinforcement Psychology medicine.drug |
| Zdroj: | Behavioural pharmacology. 19(8) |
| ISSN: | 1473-5849 |
| Popis: | Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-administration (LS and HS lines, respectively). Rats from the outbred founder population and the first selected generation were evaluated for intravenous self-administration of either morphine or cocaine. All subsequent generations were assessed for self-administration of cocaine, using a multifactorial score based on how rapidly self-administration behavior was acquired, levels of self-administration during acquisition, and the response to different doses of cocaine. All changes in cocaine self-administration that occurred in generations three through six were consistent with effects of selection, with most measures differing in sixth-generation LS and HS animals. Sixth-generation HS rats self-administered approximately five times more injections of low-dose cocaine than LS animals under fixed-ratio-5 (a schedule in which an injection is delivered after five lever presses). These findings support a role of genetic factors in influencing cocaine-reinforced behavior. Establishment of the LS and HS lines will allow future studies to evaluate the role of specific genetic factors that underlie these differences and may contribute to substance abuse disorders in humans. |
| Databáze: | OpenAIRE |
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