Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome
Autor: | Xiao-Ping Shen, Lin Xu, Binbin Zhang, Yu Zhao, Qiao-Hong Liu, Yi-Yang Hu, Yamei Hai |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Deficiency syndrome Article Subject business.industry Spleen Traditional Chinese medicine Damp heat behavioral disciplines and activities Gastroenterology Other systems of medicine 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Complementary and alternative medicine Chronic hepatitis Medication information 030220 oncology & carcinogenesis Internal medicine medicine Hepatoprotective Drugs 030212 general & internal medicine Liver function business RZ201-999 Research Article |
Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) |
ISSN: | 1741-4288 1741-427X |
Popis: | Traditional Chinese medicine (TCM) has a long history in the treatment of chronic hepatitis B (CHB) based on the syndrome identification. Previous studies reported CHB patients with damp-heat (DH) syndrome accompanied with a severe liver function damage, but lacked the medication analysis. In this study, we analyzed 999 CHB patients with unidentified individual-level data from database to explore clinical features of two common syndromes of CHB patients based on the real world. Compared with the spleen deficiency (SD) syndrome, the CHB patients with DH syndrome had a significantly higher level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ( P < 0.05 ) but took more immunomodulators and hepatoprotective drugs ( P < 0.1 ). Similarly, in the follow-up of 207 patients after 3 months, the improvement trend of ALT and AST of patients with sustained SD syndrome was significantly better than those whose TCM syndrome changed from SD to DH ( P < 0.05 ). The logistic model indicated DH syndrome was a significant negative factor for reducing ALT level in CHB patients (OR = 4.854, P = 0.032 ). This study suggests that CHB patients with DH syndrome have potentially more serious and sustained liver damage than the SD syndrome, which provides a reference for the personalized management of CHB patients from the perspective of TCM syndromes. |
Databáze: | OpenAIRE |
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