Ganglion cell layer-inner plexiform layer thickness and vision loss in young children with optic pathway gliomas
| Autor: | Robert A. Avery, Natalie C. Glaug, Sherry Gu, Avital Cnaan, Roger J. Packer |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Optic Nerve Glioma Retinal Ganglion Cells medicine.medical_specialty Visual acuity genetic structures Nerve fiber layer Visual Acuity Vision Low chemistry.chemical_compound Nerve Fibers Ophthalmology medicine Humans Abnormal Vision Child Ganglion cell layer neoplasms Retrospective Studies business.industry Retinal Anatomy Articles medicine.disease Inner plexiform layer eye diseases Ganglion medicine.anatomical_structure chemistry Child Preschool Female sense organs Optic nerve glioma medicine.symptom Visual Fields business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Investigative ophthalmologyvisual science. 55(3) |
| ISSN: | 1552-5783 |
| Popis: | To determine if measures of macular ganglion cell layer-inner plexiform layer (GCL-IPL) thickness can discriminate between children with and without vision loss (visual acuity or field) from their optic pathway glioma (OPG) using spectral-domain optical coherence tomography (SD-OCT).Children with OPGs (sporadic or secondary to neurofibromatosis type 1) enrolled in a prospective study of SD-OCT were included if they were cooperative for vision testing and macular SD-OCT images were acquired. Manual segmentation of the macular GCL-IPL and macular retinal nerve fiber layer (RNFL) was performed using elliptical annuli with diameters of 1.5, 3.0, and 4.5 mm. Logistic regression assessed the ability of GCL-IPL and RNFL thickness measures (micrometers) to differentiate between the normal and abnormal vision groups.Forty-seven study eyes (normal vision = 31, abnormal vision = 16) from 26 children with OPGs were included. Median age was 5.3 years (range, 2.5-12.8). Thickness of all GCL-IPL and RNFL quadrants differed between the normal and abnormal vision groups (P0.01). All GCL-IPL measures demonstrated excellent discrimination between groups (area under the curve [AUC]0.90 for all diameters). Using the lower fifth percentile threshold, the number of abnormal GCL-IPL inner macula (3.0 mm) quadrants achieved the highest AUC (0.989) and was greater than the macula RNFL AUCs (P0.05).Decreased GCL-IPL thickness (fifth percentile) can discriminate between children with and without vision loss from their OPG. Ganglion cell layer-inner plexiform layer thickness could be used as a surrogate marker of vision in children with OPGs. |
| Databáze: | OpenAIRE |
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