n-3 pufa and α-tocopherol control of tumor cell proliferation
| Autor: | Bartoli Gm, Elisabetta Piccioni, Chiara Luberto, Paola Palozza, Franceschelli P, Marcello Anti, F. Armelao, Sgarlata E, Giancarlo Marra |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer medicine.medical_treatment Clinical Biochemistry Tritium Biochemistry Epithelium chemistry.chemical_compound Fish Oils Double-Blind Method Risk Factors Internal medicine Fatty Acids Omega-3 Humans Vitamin E Medicine Tocopherol Intestinal Mucosa Molecular Biology N 3 pufa chemistry.chemical_classification business.industry Rectum Fatty acid General Medicine Fish oil medicine.disease Endocrinology Adenomatous Polyposis Coli chemistry Colonic Neoplasms Autoradiography Molecular Medicine Arachidonic acid Colorectal Neoplasms business Cell Division Thymidine Polyunsaturated fatty acid |
| Zdroj: | Molecular Aspects of Medicine. 14:247-252 |
| ISSN: | 0098-2997 |
| DOI: | 10.1016/0098-2997(93)90011-2 |
| Popis: | Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3 H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk polulation; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E. |
| Databáze: | OpenAIRE |
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