Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice
| Autor: | Anne-Charlotte Trouillet, Suzanne Ducroq, Lydie Naulé, Daphné Capela, Caroline Parmentier, Sally Radovick, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja |
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| Přispěvatelé: | Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Rutgers Robert Wood Johnson Medical School [New Brunswick, NJ, USA] (Rutgers-New Brunswick), Mhaouty-Kodja, Sakina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Neurons Estrogen Receptor alpha Hypothalamus Medicine (miscellaneous) [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology Preoptic Area General Biochemistry Genetics and Molecular Biology Mice Sexual Behavior Animal Animals [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] General Agricultural and Biological Sciences [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology |
| Zdroj: | Communications Biology Communications Biology, 2022, 5 (1), pp.383. ⟨10.1038/s42003-022-03324-w⟩ |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-022-03324-w⟩ |
| Popis: | Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced number of progesterone receptor-immunoreactive neurons in the ventromedial hypothalamus. Mutant males displayed a moderately impaired sexual behavior and unaffected fertility, despite evidences of altered organization of sexually dimorphic populations in the preoptic area. In comparison, males deleted for both neural ERα and androgen receptor (AR) displayed greater sexual deficiencies. Thus, these data highlight a predominant role for neural ERα in females and a complementary role with the AR in males in the regulation of sexual behavior, and provide a solid background for future analyses of neuronal versus glial implication of these signaling pathways in both sexes. |
| Databáze: | OpenAIRE |
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