Dosimetric evaluation of the skin-sparing effects of 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy for left breast cancer
| Autor: | In Young Jo, Seok Hyun Son, Shin-Wook Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
genetic structures
medicine.medical_treatment Planning target volume Breast Neoplasms Conformal radiotherapy 030218 nuclear medicine & medical imaging 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer otorhinolaryngologic diseases Humans Medicine In patient 3-dimensioanl conformal radiotherapy Radiometry integumentary system business.industry Radiotherapy Planning Computer-Assisted skin-sparing Cancer Radiotherapy Dosage intensity-modulated radiotherapy medicine.disease Tumor Burden Radiation therapy Left breast Treatment Outcome Oncology 030220 oncology & carcinogenesis Female Radiotherapy Intensity-Modulated radiation-related dermatitis Intensity modulated radiotherapy Radiotherapy Conformal Tomography X-Ray Computed business Nuclear medicine Organ Sparing Treatments therapeutics Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.13830 |
| Popis: | // In Young Jo 1 , Shin-Wook Kim 2 , Seok Hyun Son 2 1 Department of Radiation Oncology, Samsung Medical Center, Seoul, Korea 2 Department of Radiation Oncology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Correspondence to: Seok Hyun Son, email: sonshyun@catholic.ac.kr Keywords: breast cancer, 3-dimensioanl conformal radiotherapy, intensity-modulated radiotherapy, radiation-related dermatitis, skin-sparing Received: August 19, 2016 Accepted: December 01, 2016 Published: December 09, 2016 ABSTRACT The purpose of this study was to evaluate the skin-sparing effects of 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in patients with early left-sided breast cancer. Twenty left breast cancer patients treated with whole breast radiotherapy following breast-conserving surgery were enrolled in this study, and the 3D-CRT and IMRT plans were generated for each patient. To evaluate the dose delivered to the skin, 2 mm thickness skin (2-mm skin) and 3 mm thickness skin (3-mm skin) were contoured and a dosimetric comparison between the 2 plans was performed. The target volume coverage was better in IMRT than in 3D-CRT. The mean dose was 50.8 Gy for 3D-CRT and 51.1 Gy for IMRT. V40Gy was 99.4% for 3D-CRT and 99.9% for IMRT. In the case of skin, the mean dose was higher in 3D-CRT than in IMRT (mean dose of 2-mm skin: 32.8 Gy and 24.2 Gy; mean dose of 3-mm skin: 37.2 Gy and 27.8 Gy, for 3D-CRT and IMRT, respectively). These results indicated that the skin-sparing effect is more prominent in IMRT compared to 3D-CRT without compromising the target volume coverage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|