Response to Letter Regarding Article, 'Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet'
| Autor: | Tamas Fulop, Thomas Simmet, Rima Elhage, Amna Abderrazak, Mustapha Rouis, Dominique Couchie, Menna El Gaafary, Bertrand Friguet, Khadija El Hadri, Cécile Vindis, Tatiana Syrovets, Monica Rubio Ayala, Dler Faieeq Darweesh Mahmood, Muriel Laffargue, Berthold Büchele, Mohamed-Naceur Slimane, Véronique Mateo |
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| Přispěvatelé: | Vieillissement Cellulaire Intégré et Inflammation (VCII), Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Apolipoprotein E2 Inflammasomes [SDV.BC]Life Sciences [q-bio]/Cellular Biology Diet High-Fat Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine medicine Animals ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences integumentary system biology Cholesterol business.industry Autophagy Inflammasome biology.organism_classification Atherosclerosis In vitro 3. Good health Endocrinology chemistry Artemisia Interleukin 18 Female Cardiology and Cardiovascular Medicine business Carrier Proteins Sesquiterpenes 030215 immunology medicine.drug |
| Zdroj: | Circulation Circulation, American Heart Association, 2015, 132 (21), pp.e250-e251. ⟨10.1161/CIRCULATIONAHA.115.017739⟩ Circulation, 2015, 132 (21), pp.e250-e251. ⟨10.1161/CIRCULATIONAHA.115.017739⟩ |
| ISSN: | 0009-7322 1524-4539 |
| Popis: | In response to the letter of Drs Takahashi and Karasawa, we thought it might be of interest to open the debate about the mechanism by which arglabin, a natural compound isolated from Artemisia glabella , inhibits cholesterol crystal–induced activation of the NLRP3 inflammasome in murine macrophages. In the March 2015 online issue of Circulation 1 we evaluated the impact of arglabin on cholesterol crystal–mediated NLRP3 activation in cultured murine macrophages and in ApoE2.Ki mice fed a high-fat diet. We showed that both Nlrp3 knockout and inhibition of NLRP3 activation by the compound arglabin significantly decreased the size of atherosclerotic lesions in ApoE2.Ki mice fed a high-fat diet. At the molecular level, arglabin inhibited the activity of the NLRP3 inflammasome and significantly reduced the subsequent production of interleukin 1β (IL-1β) and interleukin 18 in vitro … |
| Databáze: | OpenAIRE |
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