Suppression of PHA-stimulated lymphocyte transformation in cynomolgus monkeys following infection with Coxiella burnetii
Autor: | J. C. Gonder, R. A. Kishimoto |
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Rok vydání: | 1979 |
Předmět: |
Male
Immunology Stimulation Lymphocyte Activation Applied Microbiology and Biotechnology Microbiology Coxiella Antigen Immunity Genetics Animals Lymphocytes Phytohemagglutinins Molecular Biology biology Convalescence Haplorhini General Medicine bacterial infections and mycoses Coxiella burnetii biology.organism_classification Antibodies Bacterial Peripheral blood Macaca fascicularis Lymphocyte transformation biology.protein Female Antibody Q Fever |
Zdroj: | Canadian Journal of Microbiology. 25:949-952 |
ISSN: | 1480-3275 0008-4166 |
DOI: | 10.1139/m79-145 |
Popis: | Phytohemagglutin-induced blastogenesis of peripheral blood lymphocytes from cynomolgus monkeys infected with Coxiella burnetii was suppressed between 14 and 28 days after infection. Lymphocytes became responsive to PHA again on day 35 with an increase in stimulation index when cultured with specific antigens. In contrast, production of specific humoral antibodies was not diminished during the acute and early convalescent stages of infection. (Author) |
Databáze: | OpenAIRE |
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