Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas
| Autor: | Naoko Nishimura, Tatsuhiko Kawarabayashi, Takehito Kawakami, Toru Hachisuga, Kazuki Nabeshima, Hiroshi Iwasaki, Peixin Dong |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adenoma
Adult Cancer Research Pathology medicine.medical_specialty Adolescent Kaplan-Meier Estimate Adenocarcinoma Biology Metastasis IQGAP1 Ovarian carcinoma medicine Humans Neoplasm Invasiveness Cytoskeleton Cell adhesion Aged Aged 80 and over Ovarian Neoplasms Middle Aged Prognosis medicine.disease Actin cytoskeleton Immunohistochemistry Oncology ras GTPase-Activating Proteins Multivariate Analysis Disease Progression Female Immunostaining Follow-Up Studies |
| Zdroj: | Cancer Letters. 243:120-127 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2005.11.024 |
| Popis: | IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E-cadherin-mediated cell adhesion. To determine the role of IQGAP1 in ovarian tumors, we evaluated IQGAP1 expression by immunohistochemistry in 17 adenomas, 30 borderline tumors and 80 adenocarcinomas and its relation with patient survival. IQGAP1 was overexpressed in adenocarcinomas compared with adenomas and borderline tumors. Enhanced immunostaining in invasive tumor fronts was categorized as focal or diffuse. The diffuse expression pattern correlated with high histological grade and clinicopathological stages. IQGAP1 overexpression and diffuse invasion pattern were significantly associated with poor prognosis by multivariate analysis. Our findings suggest the involvement of IQGAP1 in the progression and spread of ovarian adenocarcinomas. Overexpression and diffuse expression pattern of IQGAP1 are potentially useful independent molecular predictors of highly aggressive ovarian carcinomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect