Simulative structure and binding sites of lyral with olfactory receptor 10J5 using computational prediction methods
| Autor: | Rui Zhang, Pu Wang, He Wang, Shunbang Yu, Charles Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular 0301 basic medicine Protein Conformation Health Toxicology and Mutagenesis Receptors Odorant Toxicology 01 natural sciences 03 medical and health sciences Prediction methods Cyclohexenes 0103 physical sciences medicine Humans Computer Simulation Amino Acid Sequence Homology modeling Binding site Receptor Gene Aldehydes Olfactory receptor 010304 chemical physics Chemistry Cell biology 030104 developmental biology medicine.anatomical_structure Models Chemical Odor Receptors Adrenergic beta-2 Olfactory epithelium Protein Binding |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 83:1-8 |
| ISSN: | 1087-2620 1528-7394 |
| DOI: | 10.1080/15287394.2019.1706269 |
| Popis: | Olfactory receptor (OR) genes are extensively distributed throughout the human organism. Although these receptors are predominantly located in the olfactory epithelium, binding between odorant chemicals and corresponding ORs initiates downstream events in other tissues. In particular, exposure to allergen fragrances results in the induction of contact dermatitis. At present, current methodologies are limited in their ability to predict the consequences of fragrancy chemicals on humans. The aim of this study was designed to simulate the |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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