Dose Effect in Adjuvant Radiation Therapy for the Treatment of Resected Keloids
| Autor: | Steven Gresswell, Mark G. Trombetta, Paul Renz, Raymond T. Hajjar, James Fontanesi, Shaakir Hasan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Article 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Keloid medicine Adjuvant therapy Dose effect Radiology Nuclear Medicine and imaging skin and connective tissue diseases Adjuvant radiotherapy Radiation business.industry Cosmesis Retrospective cohort study medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Abdomen business |
| Zdroj: | Int J Radiat Oncol Biol Phys |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2018.05.027 |
| Popis: | PURPOSE: Surgical excision of keloids can result in an insidious cycle of tissue injury and repeat keloid formation unless combined with adjuvant therapy to halt this cycle. We present our results of postoperative radiation therapy for keloids with various dose regimens. METHODS AND MATERIALS: A retrospective review of 124 patients with 250 keloid lesions treated with postoperative radiation therapy was analyzed. In this institutional review board—approved study, 125 keloids were treated to 20 Gy in 5 fractions and 125 keloids were treated to 12 to 16 Gy in 3 to 4 fractions. Local failure was defined as redevelopment of any clinically apparent keloid at the treated site. The median age was 34 years (14-84 years). Keloids were located on the ear (34%), neck/shoulder (19%), abdomen (13%), chest (10%), face (9%), breast (7%), extremities (4%), and back (3%). Median keloid size was 4 cm (0.5-20 cm). RESULTS: At a median follow-up of 40 months, the recurrence rate for all lesions was 5.6%. Lesions treated to 20 Gy had a recurrence rate of 1.6% compared with 9.6% with 60 (20 Gy in 5 fractions) yielded superior local control over lower dose regimens. |
| Databáze: | OpenAIRE |
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