Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions
| Autor: | Sarah Minner, Udo Schumacher, Jakob R. Izbicki, Christoph Plass, Anna Heinl, Jan O. Korbel, Klaus Pantel, Hüseyin Sirma, Antje Krohn, Pascale Sophia Mayer, Thorsten Schlomm, Ronald Simon, Ekkehard Dikomey, Martina Kluth, Katharina Grupp, Guido Sauter, Jana Hesse, Stefan Steurer |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Biochemical recurrence PCA3 Pathology medicine.medical_specialty Oncogene Proteins Fusion Blotting Western Biology MAP3K7 Polymerase Chain Reaction TMPRSS2 Pathology and Forensic Medicine Prostate cancer Prostate Biomarkers Tumor medicine Humans In Situ Hybridization Fluorescence Aged Tissue microarray medicine.diagnostic_test Prostatic Neoplasms Middle Aged Prostate-Specific Antigen MAP Kinase Kinase Kinases medicine.disease medicine.anatomical_structure Tissue Array Analysis Cancer research Chromosomes Human Pair 6 Neoplasm Recurrence Local Gene Deletion Fluorescence in situ hybridization |
| Zdroj: | Modern Pathology. 26:975-983 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.2012.236 |
| Popis: | 6q12-22 is the second most commonly deleted genomic region in prostate cancer. Mapping studies have described a minimally deleted area at 6q15, containing MAP3K7/TAK1, which was recently shown to have tumor suppressive properties. To determine prevalence and clinical significance of MAP3K7 alterations in prostate cancer, a tissue microarray containing 4699 prostate cancer samples was analyzed by fluorescence in situ hybridization. Heterozygous MAP3K7 deletions were found in 18.48% of 2289 interpretable prostate cancers. MAP3K7 deletions were significantly associated with advanced tumor stage (P |
| Databáze: | OpenAIRE |
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