Pretreatment with Salvadora persica L. (Miswak) aqueous extract alleviates paracetamol-induced hepatotoxicity, nephrotoxicity, and hematological toxicity in male mice
| Autor: | Mohammed A Qumani, Shahid M Syed, Tolgahan Acar, Hossain Ashfaque, Khalil I Altaif, Mohamed J. Saadh, Bahaa Al-Trad, Mohd Alaraj, Irena Kosińska, Ammar Almaaytah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
kidney
mice Bilirubin paracetamol Veterinary medicine salvadora persica l 010501 environmental sciences Pharmacology liver 01 natural sciences SF1-1100 Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Salvadora persica White blood cell SF600-1100 medicine skin and connective tissue diseases 0105 earth and related environmental sciences Creatinine Kidney General Veterinary biology business.industry urogenital system hematology biology.organism_classification Animal culture medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Toxicity Uric acid business Research Article |
| Zdroj: | Veterinary World, Vol 14, Iss 3, Pp 589-594 (2021) Veterinary World |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Background and Aim: Paracetamol (PCM) ingestion is one of the most frequent global causes of toxicity. Salvadora persica L. is a plant that among many other effects exhibits potent antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. In this study, we investigated the possible protective effect of S. persica aqueous extract in the PCM overdose-induced liver and kidney injury and hematological changes in a mice model. Materials and Methods: Mice were given PCM with and without S. persica pretreatment. Blood cell counts and liver and kidney function biomarkers were measured. Liver and kidney samples were histologically examined. Results: A single overdose of PCM caused significant elevations of alanine and aspartate transaminases, alkaline phosphate, bilirubin, urea, uric acid, and creatinine compared with the control group. In addition, PCM toxicity significantly lowered red blood cell count but insignificantly increased both white blood cell and platelet counts in comparison to the control mice. Pretreatment with S. persica significantly prevented PCM-induced changes in hepatic and renal biomarkers. S. persica also caused marked reversal of hematological changes. Histologically, the liver and kidney showed inflammation and necrosis after PCM treatment, which were significantly reduced in mice pretreated with S. persica. Conclusion: Taken together, S. persica significantly inhibited PCM-induced renal, hepatic, and hematological toxicity, pointing to its possible use in the treatment of liver and renal disorders. |
| Databáze: | OpenAIRE |
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