New circulation of genotype V of Crimean-Congo haemorrhagic fever virus in humans from Spain
| Autor: | Moncef Belhassen-García, Lía Monsalve Arteaga, Juan Luis Muñoz Bellido, Jorge García Criado, María Belén Vicente Santiago, Nuria Leralta, María Carmen Vieira Lista, Jesús Ángel Sánchez Serrano, Antonio Muro, Amparo López Bernús, Fernando de Ory Manchón, Montserrat Alonso Sardón, María Paz Sánchez Seco, Ana Isabel Negredo |
|---|---|
| Přispěvatelé: | Instituto de Salud Carlos III - ISCIII, European Regional Development Fund (ERDF/FEDER), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Enfermedades Tropicales |
| Rok vydání: | 2021 |
| Předmět: |
Male
Crimean–Congo hemorrhagic fever Critical Care and Emergency Medicine Pulmonology Epidemiology RC955-962 Social Sciences Geographical locations 0302 clinical medicine Arctic medicine. Tropical medicine Genotype Psychology Prospective Studies 030212 general & internal medicine Phylogeny Neglected tropical diseases media_common Aged 80 and over Geography Animal Behavior Middle Aged Europe Phylogeography Infectious Diseases Biogeography Hemorrhagic Fever Virus Crimean-Congo Crimean-Congo hemorrhagic fever Ethnology Female Public aspects of medicine RA1-1270 Research Article Medical conditions 030231 tropical medicine Crimean-Congo haemorrhagic fever virus Viral diseases Respiratory Disorders 03 medical and health sciences Genetics medicine Humans media_common.cataloged_instance European Union European union Aged Medicine and health sciences Evolutionary Biology Behavior Population Biology Tropical diseases Ecology and Environmental Sciences Public Health Environmental and Occupational Health Biology and Life Sciences Sequence Analysis DNA medicine.disease Cross-Sectional Studies Immunoglobulin M Spain Immunoglobulin G Medical Risk Factors DNA Viral Respiratory Infections Earth Sciences Hemorrhagic Fever Crimean Animal Migration People and places Zoology Viral hemorrhagic fevers Population Genetics |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009197 (2021) |
| Popis: | Background Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral disease caused by the Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV has been implicated in severe viral haemorrhagic fever outbreaks. During the summer of 2016, the first two cases with genotype III (Africa 3) were reported in Spain. The first objective of our study was to determine the presence of CCHFV among patients with febrile illness during the spring and summer periods in 2017 and 2018. Finally, we perform a phylogenetic analysis to determine the genotype of the virus. Methodology We prospectively evaluated patients aged 18 years and older who came to the emergency department at the Salamanca’s University Hospital (HUS) with fever. Specific IgM and IgG antibodies against CCHFV by ELISA and one immunofluorescence assay against two different proteins (nucleoprotein and glycoprotein C) was done. Moreover, molecular detection by Real Time PCR was performed in all collected samples. A phylogenetic analysis was carried out to genetically characterize CCHFV detected in this study. Principal findings A total of 133 patients were selected. The mean age was 67.63 years and 60.9% were male. One-third of the patients presented an acute undifferentiated febrile illness. Three patients had anti-CCHFV IgG antibodies, suggesting a previous infection. One patient had anti-CCHFV IgM antibodies and a confirmatory RT-PCR. Phylogenetic analysis indicated that the virus corresponds to the European genotype V. This patient came to the emergency department at HUS in August 2018 presenting an acute febrile syndrome with thrombopenia and liver impairment. Conclusions We describe a new circulation of European genotype V CCHFV in Spain. Moreover, this study suggests that CCHFV is an identifiable cause of febrile illness of unknown origin in Spain. Thus, CCHF could be suspected in patients with fever, liver damage, and/or haemorrhagic disorders, particularly in people with risk activities who present in the spring or summer. Author summary Crimean Congo hemorrhagic fever (CCHF) is a widespread tick-borne viral disease caused by a Nairovirus of the Bunyaviridae family. CCHFV has been considered to be one of the eight priority emergent pathogens for the last 3 years by the World Health Organization (WHO), requiring urgent attention in Research, Development and Innovation (R&D&I) because of its epidemic potential in the near future In this study, we describe a new circulation of European genotype V CCHFV in Spain. Moreover, this study suggests that CCHFV is an identifiable cause of febrile illness of unknown origin in Spain. Thus, CCHF could be suspected in patients with fever, liver damage, and/or haemorrhagic disorders, particularly in people with risk activities who present in the spring or summer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|