Long-term suppression of the development of complementary memory storage sites in mice: functional interdependence of acetylcholine and dopamine
| Autor: | Josefa B. Flexner, Allen C. Church, Louis B. Flexner |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Dopamine Clinical Biochemistry Scopolamine Amnesia Toxicology Biochemistry Behavioral Neuroscience Mice Memory Muscarinic acetylcholine receptor Haloperidol medicine Animals Memory disorder Biological Psychiatry Pharmacology Receptors Dopamine D2 Receptors Dopamine D1 Dopaminergic Dopamine antagonist Muscarinic antagonist Brain medicine.disease Acetylcholine Cholinergic Female Puromycin medicine.symptom Psychology Neuroscience medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 43(2) |
| ISSN: | 0091-3057 |
| Popis: | Bitemporal injections of puromycin consistently induce amnesia of aversive maze learning in mice when given within 3 days after training. These injections consistently fail to induce amnesia when given 6 or more days after training. Consistent with the evidence from other laboratories, we interpret these results to indicate that the initial, temporal memory storage sites are supplemented 6 days after training by the development of complementary storage sites in other cerebral areas. Previous experiments have shown that this process is suppressed for 30-60 days by a single SC injection of scopolamine, a muscarinic antagonist. We now find that this suppressive action of scopolamine can be completely nullified by haloperidol, a dopaminergic antagonist. This finding supports the view that there may be a therapeutic role for dopamine antagonists in the treatment of cognitive dysfunction associated with cholinergic loss. |
| Databáze: | OpenAIRE |
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