Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy

Autor: Marianne Terese Huben, Bolanle Gbadamosi, Ming Xie, Daniel Ezekwudo, Bhadresh Nayak, Colvin Robert, Sandra Gjorgova-Gjeorgjievski, Ishmael Jaiyesimi, Zhou Yu
Rok vydání: 2018
Předmět:
Zdroj: Case Reports in Immunology
Case Reports in Immunology, Vol 2018 (2018)
ISSN: 2090-6617
2090-6609
DOI: 10.1155/2018/4520294
Popis: Malignant melanoma is responsible for the majority of skin cancer deaths and is increasing in prevalence. Bone marrow (BM) involvement by melanoma is rare in the absence of widespread visceral disease. Here, we report the case of a 30-year-old female who presented to the hospital with back pain, low-grade fever, and easy bruising. She was found to be bicytopenic and in disseminated intravascular coagulopathy (DIC). Surprisingly, BM biopsy showed extensive involvement by metastatic malignant melanoma in the absence of visceral or brain metastasis. The unique presentation of this case and the challenge of management of a potentially treatable cancer in a critically ill patient are discussed, alongside a review of published cases of metastatic melanoma in the BM and an exploration of currently available treatment options. The excellent response of our patient to combined immune checkpoint inhibitors has yet to be paralleled in the available literature.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje