Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women
| Autor: | Jan Willem van der Steeg, J. Dik F. Habbema, Pieternel Steures, Fulco van der Veen, Marinus J.C. Eijkemans, Peter G.A. Hompes, G. Jur E. Oosterhuis, Jan M. Burggraaff, Ben W.J. Mol, Patrick M.M. Bossuyt |
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| Přispěvatelé: | APH - Amsterdam Public Health, Obstetrics and Gynaecology, Epidemiology and Data Science, ARD - Amsterdam Reproduction and Development, Center for Reproductive Medicine, Obstetrics and gynaecology, Neuroscience Campus Amsterdam 2008, ICaR - Ischemia and repair, Public Health, Radiology & Nuclear Medicine |
| Rok vydání: | 2008 |
| Předmět: |
Infertility
Adult Male Ovulation medicine.medical_specialty Pregnancy Rate Population Body Mass Index Cohort Studies SDG 3 - Good Health and Well-being Pregnancy Spontaneous conception Medicine Humans Obesity Prospective Studies education Probability Gynecology education.field_of_study business.industry Rehabilitation Hazard ratio Obstetrics and Gynecology Middle Aged medicine.disease Pregnancy rate Reproductive Medicine Gestation Female business Body mass index Infertility Female Follow-Up Studies |
| Zdroj: | Human reproduction (Oxford, England), 23(2), 324-328. Oxford University Press van der Steeg, J W, Steures, P, Eijkemans, M J C, Habbema, J D F, Hompes, P G A, Burggraaff, J M, Oosterhuis, G J E, Bossuyt, P M M, van der Veen, F & Mol, B W J 2008, ' Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women ', Human Reproduction, vol. 23, no. 2, pp. 324-328 . https://doi.org/10.1093/humrep/dem371 Human Reproduction, 23(2), 324-328. Oxford University Press |
| ISSN: | 0268-1161 |
| DOI: | 10.1093/humrep/dem371 |
| Popis: | Background: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. Methods: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. Results: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m(2). Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m(2) increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. Conclusions: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women. |
| Databáze: | OpenAIRE |
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