Cellular resolution imaging of neuronal activity across space and time in the mammalian brain
| Autor: | Jerry L. Chen, Mitchell Clough |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
education.field_of_study Computer science Population Biomedical Engineering Medicine (miscellaneous) Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology ENCODE Mammalian brain Network dynamics Article Biomaterials 03 medical and health sciences Neuroimaging Cellular resolution Premovement neuronal activity 0210 nano-technology education Neuroscience 030304 developmental biology |
| Zdroj: | Curr Opin Biomed Eng |
| ISSN: | 2468-4511 |
| Popis: | The action potential has long been understood to be the fundamental bit of information in brain, but how these spikes encode representations of stimuli and drive behavior remains unclear. Large-scale neuronal recordings with cellular and spike-time resolution spanning multiple brain regions are needed to capture relevant network dynamics that can be sparse and distributed across the population. This review focuses on recent advancements in optical methods that have pushed the boundaries for simultaneous population recordings at increasing volumes, distances, depths, and speeds. The integration of these technologies will be critical for overcoming fundamental limits in the pursuit of whole brain imaging in mammalian species. |
| Databáze: | OpenAIRE |
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