Electric-Potential-Assisted Crystallisation of L-Isoleucine: A Study of Nucleation Kinetics and Its Associated Parameters
| Autor: | Mohd Nazli Naim, Noor Fitrah Abu Bakar, Muhamad Fitri Othman, Nik Salwani Md Azmi, Nornizar Anuar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
General Chemical Engineering Nucleation Thermodynamics 02 engineering and technology critical radius 010402 general chemistry 01 natural sciences nucleation kinetics Isothermal process homogeneous and heterogeneous nucleation law.invention Inorganic Chemistry Molecular dynamics electrocrystallisation law General Materials Science Critical radius Crystallization metastable zone width (MSZW) Supersaturation Crystallography polythermal and isothermal crystallisation nucleation rate 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences molecular dynamics simulation QD901-999 Electric potential 0210 nano-technology Intensity (heat transfer) |
| Zdroj: | Crystals Volume 11 Issue 6 Crystals, Vol 11, Iss 620, p 620 (2021) |
| ISSN: | 2073-4352 |
| Popis: | The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments were conducted with cooling rates of 0.1 °C/min–0.7 °C/min, whilst isothermal crystallisation was conducted with a supersaturation of 1.30–1.70, and both were carried out in a 200 mL temperature-controlled jacketed reactor. Prediction of the nucleation rate and its associated parameters for isothermal crystallisation was carried out using a molecular dynamics simulation. In both crystallisation techniques, electric potentials increased the nucleation rate, but the intensity of the electric potential had less impact on the measured parameters. Nucleation rates for 5 V isothermal crystallisation were in the order of 1010 higher than for polythermal crystallisation. Electric potential doubled the nucleation rates for polythermal crystallisation and increased the nucleation rates 12-fold in isothermal crystallisation. The isothermal technique produced the form B polymorph, but mixtures of forms A and B were produced in polythermal crystallisation. The predicted critical number of molecules, N*, and the critical radius, r*, were in good agreement with the experimental data, with a higher predicted nucleation rate in the order of 102. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|