Glucocorticoid teratogenesis in the developing nephron
| Autor: | M. R. Ogborn, J. F. S. Crocker |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Embryology
medicine.medical_specialty Hydrocortisone Offspring Health Toxicology and Mutagenesis Urinary system Gestational Age Mice Inbred Strains Biology Toxicology Mice Cystic kidney disease Pregnancy Internal medicine medicine Polycystic kidney disease Animals Maternal-Fetal Exchange Polycystic Kidney Diseases Kidney medicine.disease Endocrinology medicine.anatomical_structure Gestation Female Glucocorticoid Developmental Biology medicine.drug |
| Zdroj: | Teratology. 43:571-574 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420430611 |
| Popis: | Although the induction of polycystic kidney disease by neonatal glucocorticoid treatment has been extensively documented, there are no data on induction of polycystic kidney disease with fetal exposure to glucocorticoids. We injected groups of pregnant Swiss Webster albino mice subcutaneously with 250 mg/kg of hydrocortisone acetate on individual days from days 1 to 19 of gestation. A control group received an equal volume of saline. Histologic analysis of 1,522 kidneys from the offspring of these animals revealed no evidence of polycystic kidneys in the control group or in offspring of animals injected before day 11 of pregnancy. A bimodal distribution of cystic kidney disease was noted in the remaining animals, with highest prevalence after injection on day 12 (50.8%) and day 17 (34.3%). We conclude that 250 mg/kg of glucocorticoids may induce polycystic kidney disease in utero, but possibly only during critical periods of metanephric development. |
| Databáze: | OpenAIRE |
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