Wnt signaling is sufficient to perturb oligodendrocyte maturation
| Autor: | Mary Reid, Judith B. Grinspan, Jill See, Keith Feigenson, E. Bryan Crenshaw |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cell signaling
Programmed cell death Central nervous system Mice Transgenic Biology Cell fate determination Mice Cellular and Molecular Neuroscience Myelin Tissue culture medicine Animals Molecular Biology Cells Cultured beta Catenin Stem Cells Wnt signaling pathway Cell Differentiation Cell Biology Oligodendrocyte Wnt Proteins Oligodendroglia medicine.anatomical_structure Spinal Cord Neuroscience Myelin Proteins Signal Transduction |
| Zdroj: | Molecular and Cellular Neuroscience. 42:255-265 |
| ISSN: | 1044-7431 |
| DOI: | 10.1016/j.mcn.2009.07.010 |
| Popis: | The development of oligodendrocytes, the myelinating cells of the central nervous system, is temporally and spatially controlled by local signaling factors acting as inducers or inhibitors. Dorsal spinal cord tissue has been shown to contain inhibitors of oligodendrogliogenesis, although their identity is not completely known. We have studied the actions of one family of dorsal signaling molecules, the Wnts, on oligodendrocyte development. Using tissue culture models, we have shown that canonical Wnt activity through beta-catenin activation inhibits oligodendrocyte maturation, independently of precursor proliferation, cell death, or diversion to an alternate cell fate. Mice in which Wnt/beta-catenin signaling was constitutively activated in cells of the oligodendrocyte lineage had equal numbers of oligodendrocyte precursors relative to control littermates, but delayed appearance of mature oligodendrocytes, myelin protein, and myelinated axons during development, although these differences largely disappeared by adulthood. These results indicate that activating the Wnt/beta-catenin pathway delays the development of myelinating oligodendrocytes. |
| Databáze: | OpenAIRE |
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